Retinal Disorders in Humans and Experimental ALS Models

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dc.book.titleAnimal Models and Experimental Research in Medicine
dc.contributor.authorRojas Lozano, Pilar
dc.contributor.authorRamírez Sebastián, Ana Isabel
dc.contributor.authorHoz Montañana, María Rosa de
dc.contributor.authorCadena Santoyo, Manuel
dc.contributor.authorGarcía Martín, Elena Salobrar
dc.contributor.authorLópez Cuenca, Inés
dc.contributor.authorFernández Albarral, José Antonio
dc.contributor.authorSánchez Puebla, Lídia
dc.contributor.authorMatamoros, José A.
dc.contributor.authorSalazar Corral, Juan José
dc.contributor.authorRamirez Sebastian, Jose Manuel
dc.date.accessioned2023-06-16T13:04:01Z
dc.date.available2023-06-16T13:04:01Z
dc.date.issued2022-12-13
dc.descriptionSubmitted: July 25th, 2022 Reviewed: August 10th, 2022 Published: December 13th, 2022
dc.description.abstractAmyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease that severely impairs the patient’s mobility, as it mainly affects the upper and lower motor neurons in the spinal cord. In addition, alterations have also been demonstrated in different parts of the central nervous system (CNS), such as the brain and brainstem. The retina is a projection to the brain and is considered as a “window” to the CNS. Moreover, it is possible to use the retina as a biomarker in several neurodegenerative diseases, even in the absence of major visual impairment. Classically, it was thought that the eyes were not affected in ALS, with respect to extraocular muscles, whereas the remainder of the muscles of the body were distressed. Nevertheless, retinal changes have recently been found in this pathology and could help in diagnosis, follow-up, and even monitoring therapies in this disease.
dc.description.departmentUnidad Docente de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.statusinpress
dc.eprint.idhttps://eprints.ucm.es/id/eprint/75977
dc.identifier.doi10.5772/intechopen.107052
dc.identifier.officialurlhttps://www.intechopen.com/online-first/83435
dc.identifier.urihttps://hdl.handle.net/20.500.14352/2499
dc.language.isoeng
dc.page.initial22 p.
dc.publication.placeLondon
dc.publisherIntechOpen
dc.rightsAtribución-NoComercial 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/es/
dc.subject.cdu616.832.522: 617.7
dc.subject.cdu617.735:616.832.522
dc.subject.keywordAmyotrophic lateral sclerosis
dc.subject.keywordALS
dc.subject.keywordRetina
dc.subject.keywordAnimal models
dc.subject.keywordSOD1
dc.subject.keywordMicroglia
dc.subject.keywordProtein aggregates
dc.subject.keywordAxon pathology
dc.subject.keywordNeurodegeneration
dc.subject.keywordNeuroinflammation
dc.subject.ucmNeurociencias (Medicina)
dc.subject.ucmOftalmología
dc.subject.unesco2490 Neurociencias
dc.subject.unesco3201.09 Oftalmología
dc.titleRetinal Disorders in Humans and Experimental ALS Models
dc.typebook part
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery96eaf4c7-e811-480b-86ef-b2c0c3274977
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