Combined Immune Defect in B-Cell Lymphoproliferative Disorders Is Associated with Severe Infection and Cancer Progression

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dc.contributor.authorOchoa Grullón, Juliana Lucía
dc.contributor.authorGuevara Hoyer, Kissy
dc.contributor.authorPérez López, Cristina
dc.contributor.authorPérez de Diego, Rebeca
dc.contributor.authorPeña Cortijo, Ascensión
dc.contributor.authorPolo, Marta
dc.contributor.authorMateo Morales, Marta
dc.contributor.authorAnguita Mandley, Eduardo
dc.contributor.authorJiménez García, Carlos
dc.contributor.authorBolaños, Estefanía
dc.contributor.authorÍñigo, Belén
dc.contributor.authorMedina, Fiorella
dc.contributor.authorRodríguez de la Peña, Antonia
dc.contributor.authorIzquierdo Delgado, Carmen
dc.contributor.authorFuente Muñoz, Eduardo de la
dc.contributor.authorMayol, Elsa
dc.contributor.authorFernandez Arquero, Miguel
dc.contributor.authorGonzález Fernández, Ataúlfo
dc.contributor.authorBenavente Cuesta, Celina
dc.contributor.authorSánchez Ramón, Silvia María
dc.date.accessioned2023-06-22T11:13:58Z
dc.date.available2023-06-22T11:13:58Z
dc.date.issued2022-08-19
dc.descriptionThis research received no external funding. K.G.-H is supported by The European Social Fund (ESF) through a Río Ortega Grant for Health Research Projects by the Carlos III Health Institute (ISCIII) (CM20/00098).
dc.description.abstractB cell chronic lymphoproliferative diseases (B-CLPD) are associated with secondary antibody deficiency and other innate and adaptive immune defects, whose impact on infectious risk has not been systematically addressed. We performed an immunological analysis of a cohort of 83 B-CLPD patients with recurrent and/or severe infections to ascertain the clinical relevance of the immune deficiency expression. B-cell defects were present in all patients. Patients with combined immune defect had a 3.69-fold higher risk for severe infection (p = 0.001) than those with predominantly antibody defect. Interestingly, by Kaplan–Meier analysis, combined immune defect showed an earlier progression of cancer with a hazard ratio of 3.21, than predominantly antibody defect (p = 0.005). When B-CLPD were classified in low-degree, high-degree, and plasma cell dyscrasias, risk of severe disease and cancer progression significantly diverged in combined immune defect, compared with predominantly antibody defect (p = 0.001). Remarkably, an underlying primary immunodeficiency (PID) was suspected in 12 patients (14%), due to prior history of infections, autoimmune and granulomatous conditions, atypical or variegated course and compatible biological data. This first proposed SID classification might have relevant clinical implications, in terms of predicting severe infections and cancer progression, and might be applied to different B-CLPD entities.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/78203
dc.identifier.doi10.3390/biomedicines10082020
dc.identifier.issn2227-9059
dc.identifier.officialurlhttps://doi.org/10.3390/biomedicines10082020
dc.identifier.relatedurlhttps://www.mdpi.com/journal/biomedicines
dc.identifier.urihttps://hdl.handle.net/20.500.14352/72231
dc.issue.number8
dc.journal.titleBiomedicines
dc.language.isoeng
dc.page.initial2020
dc.publisherMDPI
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu612.017
dc.subject.keywordB cell chronic lymphoproliferative disorders
dc.subject.keywordSevere infections
dc.subject.keywordSecondary immunodeficiency
dc.subject.keywordPredominantly antibody defect
dc.subject.keywordCombine immune defect
dc.subject.keywordCancer progression
dc.subject.ucmMedicina
dc.subject.ucmInmunología
dc.subject.ucmOncología
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco2412 Inmunología
dc.subject.unesco3201.01 Oncología
dc.titleCombined Immune Defect in B-Cell Lymphoproliferative Disorders Is Associated with Severe Infection and Cancer Progression
dc.typejournal article
dc.volume.number10
dspace.entity.typePublication
relation.isAuthorOfPublication61097257-cbc3-4a0b-936a-9d07bc0cb6ce
relation.isAuthorOfPublication738fc59c-84c5-487c-bb7d-e392571e5479
relation.isAuthorOfPublicationbea59590-c16b-4e29-b8d6-d7b2133b4533
relation.isAuthorOfPublication.latestForDiscovery61097257-cbc3-4a0b-936a-9d07bc0cb6ce
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