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Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model

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dc.contributor.authorRuiz-Roso Guerra, María Belén
dc.contributor.authorEcheverry Alzate, Víctor
dc.contributor.authorRuiz-Roso Calvo De La Mora, Baltasar
dc.contributor.authorQuintela, José
dc.contributor.authorBallesteros Rodrigálvarez, Sandra María
dc.contributor.authorLahera Julia, Vicente
dc.contributor.authorHeras Jiménez, Natalia De Las
dc.contributor.authorLópez Moreno, José Antonio
dc.contributor.authorMartín Fernández, Beatriz
dc.date.accessioned2023-06-17T23:57:16Z
dc.date.available2023-06-17T23:57:16Z
dc.date.issued2018
dc.description.abstractAlzheimer’s disease (AD) is the main cause of dementia and cognitive impairment. It has been associated with a significant diminution of omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) levels in the brain. Clinical trials with DHA as a treatment in neurological diseases have shown inconsistent results. Previously, we reported that the presence of phytanic acid (PhA) in standard DHA compositions could be blunting DHA’s beneficial effects. Therefore, we aimed to analyze the effects of a low PhA-concentrated DHA and a standard PhA-concentrated DHA in Apolipoprotein E knockout (ApoEen
dc.description.departmentDepto. de Nutrición y Ciencia de los Alimentos
dc.description.departmentDepto. de Fisiología
dc.description.departmentDepto. de Psicobiología y Metodología en Ciencias del Comportamiento
dc.description.facultyFac. de Farmacia
dc.description.facultyFac. de Medicina
dc.description.facultyFac. de Psicología
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipFondo de Investigación Sanitaria (Red de Trastornos Adictivos, Fondo Europeo de Desarrollo Regional)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/62162
dc.identifier.citationRuiz-Roso Guerra, M. B., Echeverry Alzate, V., Ruiz-Roso Calvo De La Mora, B. et al. «Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model». Nutrients, vol. 11, n.o 1, diciembre de 2018, p. 11. DOI.org (Crossref), https://doi.org/10.3390/nu11010011.
dc.identifier.doi10.3390/nu11010011
dc.identifier.issn2072-6643
dc.identifier.officialurlhttps://doi.org/10.3390/nu11010011
dc.identifier.relatedurlhttps://www.mdpi.com/2072-6643/11/1/11
dc.identifier.urihttps://hdl.handle.net/20.500.14352/19079
dc.issue.number1
dc.journal.titleNutrients
dc.language.isoeng
dc.page.initial11
dc.publisherMDPI
dc.relation.projectID(RTC-2014-1689-1)
dc.relation.projectIDRD16/0017/0008
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordAlzheimer’s
dc.subject.keywordDHA
dc.subject.keywordApoE -/-
dc.subject.keywordPhytanic acid
dc.subject.keywordInflammation
dc.subject.keywordNeuroprotection
dc.subject.keywordOxidation
dc.subject.ucmNeurociencias (Medicina)
dc.subject.unesco2490 Neurociencias
dc.titleLow Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Modelen
dc.typejournal article
dc.volume.number11
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery9621ac4d-2250-42b0-86a7-7a884f605137

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