Osteogenic Effect of ZnO-Mesoporous Glasses loaded with Osteostatin

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dc.contributor.authorPérez, Rebeca
dc.contributor.authorSánchez-Salcedo, Sandra
dc.contributor.authorLozano Borregón, Daniel
dc.contributor.authorHeras, Clara
dc.contributor.authorEsbrit, Pedro
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.authorSalinas Sánchez, Antonio J.
dc.date.accessioned2023-06-17T12:28:50Z
dc.date.available2023-06-17T12:28:50Z
dc.date.issued2018-08-04
dc.descriptionRESEARCHER ID N-4501-2014 (Sandra Sánchez Salcedo) ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo) RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón) ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) RESEARCHER ID M-3316-2014 (Antonio Salinas Sánchez) ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)
dc.description.abstractMesoporous Bioactive Glasses (MBGs) are a family of bioceramics widely investigated for their putative clinical use as scaffolds for bone regeneration. Their outstanding textural properties determine high bioactivity when compared with other bioactive materials. Moreover, their great pore volumes allow these glasses to be loaded with a wide range of biomolecules to stimulate new bone formation. In this study, an MBG with composition, in mol-%, 80%SiO2–15%CaO–5%P2O5 (Blank, BL) was compared with two analogous glasses containing 4% and 5% of ZnO (4ZN and 5ZN) before and after impregnation with osteostatin, a C-terminal peptide from parathyroid hormone-related protein (PTHrP107-111). Zn2+ ions were included in the glass for their bone growth stimulator properties, whereas osteostatin was added by its osteogenic properties. Glasses were characterized, and their cytocompatibility investigated in pre-osteoblastic MC3T3-E1 cell cultures. The simultaneous additions of osteostatin and Zn2+ ions provoked enhanced MC3T3-E1 cell viability and higher differentiation capacity, compared with either raw BL or MBGs supplemented only with osteostatin or Zn2+. These in vitro results show that osteostatin enhances the osteogenic effect of Zn2+-enriched glasses, suggesting the potential of this combined approach in bone tissue engineering applications.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. H2020
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/49013
dc.identifier.doi10.3390/nano8080592
dc.identifier.issn2079-4991
dc.identifier.officialurlhttp://www.mdpi.com/journal/nanomaterials
dc.identifier.relatedurlhttp://www.ucm.es/valletregigroup
dc.identifier.urihttps://hdl.handle.net/20.500.14352/12227
dc.issue.number8
dc.journal.titleNanomaterials
dc.language.isoeng
dc.page.initial592
dc.publisherMDPI AG
dc.relation.projectIDVERDI (694160)
dc.relation.projectIDMAT2015-64831-R
dc.relation.projectID(PI15/00978)
dc.rights.accessRightsopen access
dc.subject.cdu546
dc.subject.cdu615.46
dc.subject.keywordMesoporous glasses
dc.subject.keywordZnO-additions
dc.subject.keywordOsteostatin loading
dc.subject.keywordOsteosteoblast cell cultures
dc.subject.keywordOsteogenic effect
dc.subject.ucmMateriales
dc.subject.ucmQuímica inorgánica (Farmacia)
dc.subject.unesco3312 Tecnología de Materiales
dc.titleOsteogenic Effect of ZnO-Mesoporous Glasses loaded with Osteostatin
dc.typejournal article
dc.volume.number8
dspace.entity.typePublication
relation.isAuthorOfPublicationbf1fb240-43ed-4474-8dc0-2491074f4ad3
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscoverybf1fb240-43ed-4474-8dc0-2491074f4ad3
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