Association of extended-spectrum β-lactamase VEB-5 and 16S rRNA methyltransferase armA in Salmonella enterica from the United Kingdom

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dc.contributor.authorHidalgo, Laura
dc.contributor.authorHopkins, Katie L
dc.contributor.authorWareham, David W
dc.contributor.authorGutiérrez, Belén
dc.contributor.authorGonzález Zorn, Bruno
dc.date.accessioned2023-06-20T04:19:31Z
dc.date.available2023-06-20T04:19:31Z
dc.date.issued2012-09
dc.description.abstractAminoglycosides and beta-lactams are used for the treatment of a wide range of infections due to both Gram-negative and Gram-positive. An emerging aminoglycoside resistance mechanism, methylation of the aminoacyl site of the 16S rRNA, confers high-level resistance to clinically important aminoglycosides such as amikacin, tobramycin and gentamicin. Eight 16S rRNA methyltransferase genes, armA, rmtA, rmtB, rmtC, rmtD, rmtE, rmtF and npmA, have been identified in several species of enterobacteria worldwide (2, 6, 7, 9, 11, 13, 14). Resistance to extended spectrum β-lactams remains additionally an important clinical problem. Apart from the large TEM, SHV, and CTX-M families, several other extended-spectrum β-lactamases (ESBLs) have been identified, including VEB enzymes, which confer high-level resistance to cephalosporins and monobactams. Although 16S rRNA methyltransferases have been frequently identified associated with different ESBLs, there has been no report of association of a 16S rRNA methyltransferase with a VEB enzyme, except for the identification of rmtC with blaVEB-6 (14)
dc.description.facultyCentro de Vigilancia Sanitaria Veterinaria (VISAVET)
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. FP7
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/39669
dc.identifier.doi10.1128/AAC.00381-12
dc.identifier.issn1098-6596
dc.identifier.officialurlhttp://aac.asm.org/content/56/9/4985.full
dc.identifier.urihttps://hdl.handle.net/20.500.14352/45169
dc.issue.number9
dc.journal.titleAntimicrobial agents and chemotherapy
dc.language.isoeng
dc.page.final7
dc.page.initial4985
dc.publisherAmerican Society for Microbiology
dc.relation.projectIDEVOTAR (282004)
dc.relation.projectIDBIO 2010-20204
dc.relation.projectIDPRI-PIBIN-2011-0915
dc.relation.projectIDBFU2011-14145-E
dc.relation.projectIDVIGILANCIA SANITARIA-CM (S2009/AGR-1489)
dc.rights.accessRightsrestricted access
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleAssociation of extended-spectrum β-lactamase VEB-5 and 16S rRNA methyltransferase armA in Salmonella enterica from the United Kingdom
dc.typejournal article
dc.volume.number56
dspace.entity.typePublication
relation.isAuthorOfPublicationabbfe61a-3e58-4cfb-85fc-d2e2ec46b0a3
relation.isAuthorOfPublication.latestForDiscoveryabbfe61a-3e58-4cfb-85fc-d2e2ec46b0a3
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