Role of lipid ordered/disordered phase coexistence in pulmonary surfactant function

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dc.contributor.authorCasals Carro, María Cristina
dc.contributor.authorCañadas Benito, Olga
dc.date.accessioned2024-01-15T14:04:54Z
dc.date.available2024-01-15T14:04:54Z
dc.date.issued2012-05-31
dc.description.abstractThe respiratory epithelium has evolved to produce a complicated network of extracellular membranes that are essential for breathing and, ultimately, survival. Surfactant membranes form a stable monolayer at the air-liquid interface with bilayer structures attached to it. By reducing the surface tension at the air-liquid interface, surfactant stabilizes the lung against collapse and facilitates inflation. The special composition of surfactant membranes results in the coexistence of two distinct micrometer-sized ordered/disordered phases maintained up to physiological temperatures. Phase coexistence might facilitate monolayer folding to form three-dimensional structures during exhalation and hence allow the film to attain minimal surface tension. These folded structures may act as a membrane reserve and attenuate the increase in membrane tension during inspiration. The present review summarizes what is known of ordered/disordered lipid phase coexistence in lung surfactant, paying attention to the possible role played by domain boundaries in the monolayer-to-multilayer transition, and the correlations of biophysical inactivation of pulmonary surfactant with alterations in phase coexistence.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MCIN)
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.statuspub
dc.identifier.citationCasals C, Cañadas O. Role of lipid ordered/disordered phase coexistence in pulmonary surfactant function. Biochim Biophys Acta-Biomembranes. 2012; 1818(11):2550-62
dc.identifier.doi10.1016/j.bbamem.2012.05.024
dc.identifier.issn0005-2736
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0005273612001824
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93133
dc.issue.number11
dc.journal.titleBiochimica et Biophysica Acta (BBA) - Biomembranes
dc.language.isoeng
dc.page.final2562
dc.page.initial2550
dc.publisherElsevier
dc.relation.projectID(SAF2009-07810)
dc.relation.projectID(CIBERES-CB06/06/ 0002)
dc.rights.accessRightsrestricted access
dc.subject.cdu577.112
dc.subject.cdu612.2
dc.subject.keywordLateral phase separation
dc.subject.keywordSP-A
dc.subject.keywordSP-B
dc.subject.keywordSP-C
dc.subject.keywordSurface activity
dc.subject.keywordSurfactant inhibition
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmFisiología
dc.subject.unesco2302 Bioquímica
dc.subject.unesco2411.17 Fisiología de la Respiración
dc.titleRole of lipid ordered/disordered phase coexistence in pulmonary surfactant function
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number1818
dspace.entity.typePublication
relation.isAuthorOfPublicationd4e23d80-fa5c-4614-bd2d-2c391b596713
relation.isAuthorOfPublication25a89a2f-a381-4f15-9a6b-59430ee96a63
relation.isAuthorOfPublication.latestForDiscovery25a89a2f-a381-4f15-9a6b-59430ee96a63
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