Programmed versus non-programmed evolution of aging. What is the evidence?

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dc.contributor.authorPamplona, Reinald
dc.contributor.authorJové, Mariona
dc.contributor.authorGómez, José
dc.contributor.authorBarja De Quiroga Losada, Gustavo
dc.date.accessioned2025-07-14T08:12:33Z
dc.date.available2025-07-14T08:12:33Z
dc.date.issued2023-05
dc.descriptionThe authors were supported by the Spanish Ministry of Science and Innovation, the Autonomous Government of the Community of Madrid, and the Generalitat of Catalonia (2021SGR00990). Mariona Jové is a “Serra Hunter” Fellow.
dc.description.abstractThe evolutionary meaning and basic molecular mechanisms involved in the determination of longevity remain an unresolved problem. Currently, different theories are on offer in response to these biological traits and to explain the enormous range of longevities observed in the animal kingdom. These theories may be grouped into those that defend non-programmed aging (non-PA) and those that propose the existence of programmed aging (PA). In the present article we examine many observational and experimental data from both the field and from the laboratory and sound reasoning accumulated in recent decades both compatible and not with PA and non-PA evolutionary theories of aging. These analyses are briefly summarized and discussed. Our conclusion is that most of the data favour programmed aging with a possible contribution of non-PA antagonist pleiotropy in various cases.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipGeneralitat de Catalunya
dc.description.statuspub
dc.identifier.citationPamplona, R., Jové, M., Gómez, J., & Barja, G. (2023). Programmed versus non-programmed evolution of aging. What is the evidence? [Review of Programmed versus non-programmed evolution of aging. What is the evidence?]. Experimental Gerontology, 175. Elsevier Inc. https://doi.org/10.1016/J.EXGER.2023.112162
dc.identifier.doi10.1016/j.exger.2023.112162
dc.identifier.essn1873-6815
dc.identifier.issn0531-5565
dc.identifier.officialurlhttps://doi.org/10.1016/j.exger.2023.112162
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S0531556523000839?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/122483
dc.issue.number112162
dc.journal.titleExperimental Gerontology
dc.language.isoeng
dc.page.final11
dc.page.initial1
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu591.1
dc.subject.cdu591.15
dc.subject.cdu591.3
dc.subject.keywordRate of aging
dc.subject.keywordSignalling pathways
dc.subject.keywordMetabolic phenotypes
dc.subject.keywordEvolution
dc.subject.keywordPro-longevity dietary interventions
dc.subject.keywordAnimal longevity
dc.subject.ucmZoología
dc.subject.ucmFisiología animal (Biología)
dc.subject.ucmGenética
dc.subject.unesco2401 Biología Animal (Zoología)
dc.subject.unesco2401.13 Fisiología Animal
dc.subject.unesco2401.08 Genética Animal
dc.subject.unesco2401.05 desarrollo Animal
dc.titleProgrammed versus non-programmed evolution of aging. What is the evidence?
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number175
dspace.entity.typePublication
relation.isAuthorOfPublication832e5933-f640-4442-a205-5872edef1506
relation.isAuthorOfPublication.latestForDiscovery832e5933-f640-4442-a205-5872edef1506

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