Hybrid Decorated Core@Shell Janus Nanoparticles as a Flexible Platform for Targeted Multimodal Molecular Bioimaging of Cancer
dc.contributor.author | Sánchez, Alfredo | |
dc.contributor.author | Ovejero Paredes, Karina | |
dc.contributor.author | Ruiz-Cabello, Jesús | |
dc.contributor.author | Martínez Ruiz, María Paloma | |
dc.contributor.author | Pingarrón Carrazón, José Manuel | |
dc.contributor.author | Villalonga Santana, Reynaldo | |
dc.contributor.author | Filice, Marco | |
dc.date.accessioned | 2024-01-25T15:52:48Z | |
dc.date.available | 2024-01-25T15:52:48Z | |
dc.date.issued | 2018 | |
dc.description.abstract | In the recent years, targeted cancer theranosis, the concomitant therapeutic treatment and selective visualization of cancerous tissue, has become a powerful strategy to improve patient prognosis. In this context, targeted multimodal molecular imaging, the combination of different imaging modalities overcoming their individual limitations, has attracted great attention. Due to their unique properties, advanced nanomaterials have taken center stage in the development of theranostics. In this work, we report a novel Janus nanoplatform by combining an Fe3O4 NPs/mesoporous silica core@shell face together with an Au nanoparticle face. Due to its anisotropy, this hybrid nanomaterial enabled the orthogonal site-selective modification of each face permitting the incorporation of a targeting peptide for cancer detection (cRGD) and a fluorescent dye. Due to the intrinsic characteristics of this Janus nanoplatform together with those selectively generated on their surfaces, the resulting hybrid nanocarrier successfully promoted the in vivo tumor-targeted multimodal imaging by magnetic resonance (Fe3O4 core), computed tomography (AuNP face), and fluorescent tracking (fluorescent dye loading) in a fibrosarcoma-bearing mouse model. The achieved results endorse these hybrid Janus nanoparticles as a powerful and flexible platform with integrated imaging and carrier functionalities to be equipped with therapeutic features to generate an advanced multifunctional nanocarrier for targeted cancer theranosis. | |
dc.description.department | Depto. de Química Analítica | |
dc.description.faculty | Fac. de Ciencias Químicas | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.description.sponsorship | Ministerio de Economia y Competitividad (España) | |
dc.description.sponsorship | Comunidad de Madrid | |
dc.description.sponsorship | European Commission | |
dc.description.status | pub | |
dc.identifier.citation | A. Sánchez, K. Ovejero Paredes, J. Ruiz-Cabello, P. Martinez-Ruiz, J.M. Pingarrón, R. Villalonga, M. Filice (2018). Hybrid decorated core@shell Janus nanoparticles as flexible platform for targeted multimodal molecular bioimaging of cancer. ACS Applied Materials & Interfaces 10: 31032-31043 | |
dc.identifier.doi | 10.1021/acsami.8b10452 | |
dc.identifier.issn | 1944-8244 | |
dc.identifier.officialurl | https://doi.org/10.1021/acsami.8b10452 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/95532 | |
dc.journal.title | ACS Applied Materials & Interfaces | |
dc.language.iso | eng | |
dc.page.final | 31043 | |
dc.page.initial | 31032 | |
dc.publisher | American Chemical Society | |
dc.relation.projectID | (SEV-2015-0505) | |
dc.relation.projectID | SAF2014-59118-JIN | |
dc.relation.projectID | 2017-T1/BIO-4992 | |
dc.relation.projectID | Projects CTQ2014-58989-P, CTQ2017-87954-P, SAF2017- 844494-C2-1R, and CTQ2015-71936-REDT | |
dc.relation.projectID | (Project S2013/MIT-3029) | |
dc.relation.projectID | (Project reference B2017-BMD3731) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
dc.rights.accessRights | restricted access | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.cdu | 547 | |
dc.subject.keyword | Hybrid Janus nanoparticle | |
dc.subject.keyword | multimodal molecular imaging | |
dc.subject.keyword | MRI | |
dc.subject.keyword | CT | |
dc.subject.keyword | Fluorescence imaging | |
dc.subject.keyword | Theranosis | |
dc.subject.keyword | Drug delivery | |
dc.subject.keyword | Nanotechnology | |
dc.subject.keyword | Cancer imaging | |
dc.subject.keyword | Gold nanoparticles | |
dc.subject.keyword | Mesoporous silica nanoparticles | |
dc.subject.ucm | Ciencias Biomédicas | |
dc.subject.ucm | Ciencias | |
dc.subject.unesco | 23 Química | |
dc.subject.unesco | 32 Ciencias Médicas | |
dc.title | Hybrid Decorated Core@Shell Janus Nanoparticles as a Flexible Platform for Targeted Multimodal Molecular Bioimaging of Cancer | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 10 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | b823d526-6b46-49d9-bfef-517020250a7d | |
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relation.isAuthorOfPublication | 5a0a21c2-f525-4c2c-a3b2-ab78f25604b1 | |
relation.isAuthorOfPublication.latestForDiscovery | a681d857-88a1-4eb9-ab7d-c411c59b3f80 |
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