Hybrid Decorated Core@Shell Janus Nanoparticles as a Flexible Platform for Targeted Multimodal Molecular Bioimaging of Cancer

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dc.contributor.authorSánchez, Alfredo
dc.contributor.authorOvejero Paredes, Karina
dc.contributor.authorRuiz-Cabello, Jesús
dc.contributor.authorMartínez Ruiz, María Paloma
dc.contributor.authorPingarrón Carrazón, José Manuel
dc.contributor.authorVillalonga Santana, Reynaldo
dc.contributor.authorFilice, Marco
dc.date.accessioned2024-01-25T15:52:48Z
dc.date.available2024-01-25T15:52:48Z
dc.date.issued2018
dc.description.abstractIn the recent years, targeted cancer theranosis, the concomitant therapeutic treatment and selective visualization of cancerous tissue, has become a powerful strategy to improve patient prognosis. In this context, targeted multimodal molecular imaging, the combination of different imaging modalities overcoming their individual limitations, has attracted great attention. Due to their unique properties, advanced nanomaterials have taken center stage in the development of theranostics. In this work, we report a novel Janus nanoplatform by combining an Fe3O4 NPs/mesoporous silica core@shell face together with an Au nanoparticle face. Due to its anisotropy, this hybrid nanomaterial enabled the orthogonal site-selective modification of each face permitting the incorporation of a targeting peptide for cancer detection (cRGD) and a fluorescent dye. Due to the intrinsic characteristics of this Janus nanoplatform together with those selectively generated on their surfaces, the resulting hybrid nanocarrier successfully promoted the in vivo tumor-targeted multimodal imaging by magnetic resonance (Fe3O4 core), computed tomography (AuNP face), and fluorescent tracking (fluorescent dye loading) in a fibrosarcoma-bearing mouse model. The achieved results endorse these hybrid Janus nanoparticles as a powerful and flexible platform with integrated imaging and carrier functionalities to be equipped with therapeutic features to generate an advanced multifunctional nanocarrier for targeted cancer theranosis.
dc.description.departmentDepto. de Química Analítica
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipMinisterio de Economia y Competitividad (España)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationA. Sánchez, K. Ovejero Paredes, J. Ruiz-Cabello, P. Martinez-Ruiz, J.M. Pingarrón, R. Villalonga, M. Filice (2018). Hybrid decorated core@shell Janus nanoparticles as flexible platform for targeted multimodal molecular bioimaging of cancer. ACS Applied Materials & Interfaces 10: 31032-31043
dc.identifier.doi10.1021/acsami.8b10452
dc.identifier.issn1944-8244
dc.identifier.officialurlhttps://doi.org/10.1021/acsami.8b10452
dc.identifier.urihttps://hdl.handle.net/20.500.14352/95532
dc.journal.titleACS Applied Materials & Interfaces
dc.language.isoeng
dc.page.final31043
dc.page.initial31032
dc.publisherAmerican Chemical Society
dc.relation.projectID(SEV-2015-0505)
dc.relation.projectIDSAF2014-59118-JIN
dc.relation.projectID2017-T1/BIO-4992
dc.relation.projectIDProjects CTQ2014-58989-P, CTQ2017-87954-P, SAF2017- 844494-C2-1R, and CTQ2015-71936-REDT
dc.relation.projectID(Project S2013/MIT-3029)
dc.relation.projectID(Project reference B2017-BMD3731)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu547
dc.subject.keywordHybrid Janus nanoparticle
dc.subject.keywordmultimodal molecular imaging
dc.subject.keywordMRI
dc.subject.keywordCT
dc.subject.keywordFluorescence imaging
dc.subject.keywordTheranosis
dc.subject.keywordDrug delivery
dc.subject.keywordNanotechnology
dc.subject.keywordCancer imaging
dc.subject.keywordGold nanoparticles
dc.subject.keywordMesoporous silica nanoparticles
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmCiencias
dc.subject.unesco23 Química
dc.subject.unesco32 Ciencias Médicas
dc.titleHybrid Decorated Core@Shell Janus Nanoparticles as a Flexible Platform for Targeted Multimodal Molecular Bioimaging of Cancer
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication
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