Copper(I)-Catalyzed Click Chemistry as a Tool for the Functionalization of Nanomaterials and the Preparation of Electrochemical (Bio)Sensors

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dc.contributor.authorYáñez Sedeño, Paloma
dc.contributor.authorGonzález Cortés, Araceli
dc.contributor.authorCampuzano Ruiz, Susana
dc.contributor.authorPingarrón Carrazón, José Manuel
dc.date.accessioned2023-06-17T12:37:37Z
dc.date.available2023-06-17T12:37:37Z
dc.date.issued2019-05-24
dc.description.abstractProper functionalization of electrode surfaces and/or nanomaterials plays a crucial role in the preparation of electrochemical (bio)sensors and their resulting performance. In this context, copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has been demonstrated to be a powerful strategy due to the high yields achieved, absence of by-products and moderate conditions required both in aqueous medium and under physiological conditions. This particular chemistry offers great potential to functionalize a wide variety of electrode surfaces, nanomaterials, metallophthalocyanines (MPcs) and polymers, thus providing electrochemical platforms with improved electrocatalytic ability and allowing the stable, reproducible and functional integration of a wide range of nanomaterials and/or different biomolecules (enzymes, antibodies, nucleic acids and peptides). Considering the rapid progress in the field, and the potential of this technology, this review paper outlines the unique features imparted by this particular reaction in the development of electrochemical sensors through the discussion of representative examples of the methods mainly reported over the last five years. Special attention has been paid to electrochemical (bio)sensors prepared using nanomaterials and applied to the determination of relevant analytes at different molecular levels. Current challenges and future directions in this field are also briefly pointed out.
dc.description.departmentDepto. de Química Analítica
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/66797
dc.identifier.doi10.3390/s19102379
dc.identifier.issn1424-8220
dc.identifier.officialurlhttps://doi.org/10.3390/s19102379
dc.identifier.relatedurlhttps://www.mdpi.com/1424-8220/19/10/2379
dc.identifier.urihttps://hdl.handle.net/20.500.14352/12651
dc.issue.number10
dc.journal.titleSensors
dc.language.isoeng
dc.page.initial2379
dc.publisherMDPI
dc.relation.projectIDCTQ2015-64402-C2-1-R
dc.relation.projectIDRTI2018-096135-B-I00
dc.relation.projectIDTRANSNANOAVANSENS-CM (P2018/NMT-4349)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordcopper(I) catalyzed click chemistry
dc.subject.keywordazide-alkyne cycloaddition
dc.subject.keywordelectrochemical (bio)sensors
dc.subject.keywordnanomaterials
dc.subject.ucmQuímica analítica (Química)
dc.subject.unesco2301 Química Analítica
dc.titleCopper(I)-Catalyzed Click Chemistry as a Tool for the Functionalization of Nanomaterials and the Preparation of Electrochemical (Bio)Sensors
dc.typejournal article
dc.volume.number19
dspace.entity.typePublication
relation.isAuthorOfPublication8a730734-cdf5-4b59-b017-12e2320c872e
relation.isAuthorOfPublication6945fb1e-9c48-459d-b994-e64328c3e79b
relation.isAuthorOfPublication8808f99c-5f56-4562-839a-517626c76dad
relation.isAuthorOfPublication.latestForDiscovery8a730734-cdf5-4b59-b017-12e2320c872e
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