Effects of Alcohol Binge Drinking and Oleoylethanolamide Pretreatment in the Gut Microbiota

dc.contributor.authorRodríguez-González, Alicia
dc.contributor.authorVitali, Francesco
dc.contributor.authorMoya Montes, Marta
dc.contributor.authorDe Filippo, Carlotta
dc.contributor.authorPassani, Maria Beatrice
dc.contributor.authorOrio Ortiz, Laura
dc.date.accessioned2024-02-29T14:06:13Z
dc.date.available2024-02-29T14:06:13Z
dc.date.issued2021-11-23
dc.description.abstractIntroduction: Chronic alcohol consumption is known to cause gut dysbiosis (changes in microbiota composition and/or function, disruptive of the normal host–microbiota interactions). However, little is known about the changes that alcohol binge drinking induces in the gut microbiota. Here, we have tested the hypothesis that a protocol of alcohol binge drinking, known to induce neuroinflammation in previous studies, also promotes intestinal dysbiosis, and we explored how oleoylethanolamide (OEA, an acylethanolamide proven to counteract alcohol binge drinking-induced neuroinflammation) pretreatment modulates alcohol-induced dysbiosis. Methods: Alcohol binges were forced by gavage three times per day during 4 consecutive days; OEA pretreatment (intraperitoneal or intragastric) was administered before each alcohol gavage. Stool microbiota composition was assessed by next-generation 16S rRNA gene sequencing, prior and after the 4-day alcohol binge protocol. Results: Alcohol binge drinking reduced the richness of the gut microbiota and changed the microbial community, reducing Lactobacillus among other genera. Pretreatment with OEA in the alcohol-administered rats decreased the richness, evenness, and Shannon indices to a greater extent with respect to alcohol alone, also changing the community structure. Microbial interactions in the association network were further decreased following OEA administration in the alcohol group, with respect to the water administration. The synergistic interaction between alcohol binge and OEA was affected by the route of administration of OEA, since oral and i.p. administrations differently changed the community structure. Conclusion: Results suggest that alcohol binge drinking produces a clear dysbiosis in animals; we observed that the well-known protective actions of OEA in the context of alcohol abuse might not be related to OEA-induced changes in alcohol-induced dysbiosis. These are observational results, and thus, further research will be needed for a complete understanding of the biological significance of the observed changes.
dc.description.departmentDepto. de Psicobiología y Metodología en Ciencias del Comportamiento
dc.description.facultyFac. de Psicología
dc.description.refereedTRUE
dc.description.sponsorshipFEDER (European Union)
dc.description.sponsorshipMinisterio de Ciencia e Innovación/Agencia Estatal de Investigación (Spain)
dc.description.statuspub
dc.identifier.citationRodríguez-González A, Vitali F, Moya M, De Filippo C, Passani MB, Orio L* (2021) Effects of Alcohol Binge Drinking and Oleoylethanolamide Pretreatment in the Gut Microbiota. Front Cell Infect Microbiol. 11:731910
dc.identifier.doi10.3389/fcimb.2021.731910
dc.identifier.officialurlhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.731910/full
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101847
dc.journal.titleFrontiers in Cellular and Infection Microbiology
dc.language.isoeng
dc.page.initial731910
dc.publisherFrontiers
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099535-B-I00/ES/SEÑALIZACION DE PRODUCTOS BACTERIANOS Y ALTERACIONES NEUROINMUNES EN LOS DEFICITS NEUROPSICOLOGICOS INDUCIDOS POR EL ABUSO DE ALCOHOL/
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.keywordFecal microbiota
dc.subject.keywordAlcohol
dc.subject.keywordOEA
dc.subject.keywordMicrobiome
dc.subject.keywordSubstance abuse
dc.subject.keywordBinge
dc.subject.keywordDysbiosis
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco61 Psicología
dc.titleEffects of Alcohol Binge Drinking and Oleoylethanolamide Pretreatment in the Gut Microbiota
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication
relation.isAuthorOfPublicationf1005c11-2a54-4975-a6e1-d3290c6ed869
relation.isAuthorOfPublication8831c820-c977-43a1-b230-c1f73b8ed0f5
relation.isAuthorOfPublication.latestForDiscoveryf1005c11-2a54-4975-a6e1-d3290c6ed869
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