Melatonin expression in periodontitis and obesity: An experimental invivo investigation

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dc.contributor.authorHaugen J, Havard
dc.contributor.authorGonzález, Jerian
dc.contributor.authorVirto Ruiz, Leire
dc.contributor.authorFernández Mateos, María Del Pilar
dc.contributor.authorCano Barquilla, María Pilar
dc.contributor.authorJiménez Ortega, Vanesa
dc.contributor.authorEsquifino Parras, Ana Isabel
dc.contributor.authorSanz Alonso, Mariano
dc.date.accessioned2024-01-19T18:39:35Z
dc.date.available2024-01-19T18:39:35Z
dc.date.issued2018-06-14
dc.description.abstractBackground and objective: Melatonin deficiency has been associated with obesity and systemic inflammation. This study aims to evaluate whether melatonin could interfere with the mechanisms of co-morbidity linking obesity and periodontitis. Material and methods: Twenty-eight male Wistar rats were randomly divided in 4 groups: control group (Con) (fed with standard diet); high-fat diet group (HFD) (fed with a diet containing 35.2% fat); Con group with induced periodontitis (Con-Perio) and HFD group with induced periodontitis (HFD-Perio). To induce periodontitis, the method of oral gavages with Porphyromonas gingivalis ATCC W83K1 and Fusobacterium nucleatum DMSZ 20482 was used. Circulating melatonin levels were analyzed by multiplex immunoassays. Periodontitis was assessed by alveolar bone loss (micro-computed tomography and histology) and by surrogate inflammatory outcomes (periodontal pocket depth, modified gingival index and plaque dental index). Results: Plasma melatonin levels were significantly decreased (P < .05) in the obese rats with periodontitis when compared with controls or with either obese or periodontitis rats. Alveolar bone loss increased 27.71% (2.28 µm) in HFD-Perio group compared with the Con group. The histological analysis showed marked periodontal tissue destruction with osteoclast activity, particularly in the HFD-Perio group. A significant negative correlation (P < .05) was found between periodontal pocket depth, modified gingival index and circulating melatonin levels. Conclusion: Obese and periodontitis demonstrated significantly lower melatonin concentrations when compared with controls, but in obese rats with periodontitis these concentrations were even significantly lower when compared with either periodontitis or obese rats. These results may indicate that melatonin deficiency could be a key mechanism explaining the co-morbidity effect in the association between obesity and periodontitis.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.departmentDepto. de Biología Celular
dc.description.facultyFac. de Odontología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationVirto L, Haugen HJ, Fernández-Mateos P, Cano P, González J, Jiménez-Ortega V, Esquifino AI, Sanz M. Melatonin expression in periodontitis and obesity: An experimental in-vivo investigation. J Periodontal Res. 2018 Oct;53(5):825-831
dc.identifier.doi10.1111/jre.12571
dc.identifier.essn1600-0765
dc.identifier.issn0022-3484
dc.identifier.officialurlhttps://doi.org/10.1111/jre.12571
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/10.1111/jre.12571
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94156
dc.issue.number5
dc.journal.titleJournal of Periodontal Research
dc.language.isoeng
dc.page.final831
dc.page.initial825
dc.publisherWiley on line Library
dc.rights.accessRightsrestricted access
dc.subject.cdu615.357
dc.subject.cdu616.314.17-008.1
dc.subject.cdu616.311.2-002
dc.subject.keywordCircadian rhythms
dc.subject.keywordMelatonin
dc.subject.keywordmicro-computed tomography
dc.subject.keywordObesity
dc.subject.keywordPeriodontitis
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmOdontología (Odontología)
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmBiología molecular (Biología)
dc.subject.unesco24 Ciencias de la Vida
dc.subject.unesco2302.21 Biología Molecular
dc.subject.unesco2302 Bioquímica
dc.titleMelatonin expression in periodontitis and obesity: An experimental invivo investigation
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number53
dspace.entity.typePublication
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