In vitro antifungal activity of topical and systemic antifungal drugs against Malassezia species

Simple item page
dc.contributor.authorCarrillo‐Muñoz, Alfonso Javier
dc.contributor.authorRojas, Florencia
dc.contributor.authorTur‐Tur, Cristina
dc.contributor.authorSosa, María de los Ángeles
dc.contributor.authorOrtiz Díez, Gustavo
dc.contributor.authorMartín Espada, María Del Carmen
dc.contributor.authorPaya Vicens, María Jesús
dc.contributor.authorGiusiano, Gustavo
dc.date.accessioned2024-06-03T15:28:09Z
dc.date.available2024-06-03T15:28:09Z
dc.date.issued2013-03-18
dc.description.abstractThe strict nutritional requirements of Malassezia species make it difficult to test the antifungal susceptibility. Treatments of the chronic and recurrent infections associated with Malassezia spp. are usually ineffective. The objective of this study was to obtain in vitro susceptibility profile of 76 clinical isolates of Malassezia species against 16 antifungal drugs used for topical or systemic treatment. Isolates were identified by restriction fragment length polymorphism. Minimal inhibitory concentrations (MIC) were obtained by a modified microdilution method based on the Clinical Laboratory Standards Institute reference document M27-A3. The modifications allowed a good growth of all tested species. High in vitro antifungal activity of most tested drugs was observed, especially triazole derivatives, except for fluconazole which presented the highest MICs and widest range of concentrations. Ketoconazole and itraconazole demonstrated a great activity. Higher MICs values were obtained with Malassezia furfur indicating a low susceptibility to most of the antifungal agents tested. Malassezia sympodialis and Malassezia pachydermatis were found to be more-susceptible species than M. furfur, Malassezia globosa, Malassezia slooffiae and Malassezia restricta. Topical substances were also active but provide higher MICs than the compounds for systemic use. The differences observed in the antifungals activity and interspecies variability demonstrated the importance to studying the susceptibility profile of each species to obtain reliable information for defining an effective treatment regimen.case">M</jats:styled-content>alassezia restricta</jats:italic>. Topical substances were also active but provide higher <jats:styled-content style="fixed-case">MIC</jats:styled-content>s than the compounds for systemic use. The differences observed in the antifungals activity and interspecies variability demonstrated the importance to studying the susceptibility profile of each species to obtain reliable information for defining an effective treatment regimen.</jats:p>
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationCarrillo-Muñoz, A.J., Rojas, F., Tur-Tur, C., de los Ángeles Sosa, M., Diez, G.O., Espada, C.M., Payá, M.J. and Giusiano, G. (2013), In vitro antifungal activity of topical and systemic antifungal drugs against Malassezia species. Mycoses, 56: 571-575. https://doi.org/10.1111/myc.12076
dc.identifier.doi10.1111/myc.12076
dc.identifier.essn1439-0507
dc.identifier.issn0933-7407
dc.identifier.officialurlhttps://doi.org/10.1111/myc.12076
dc.identifier.urihttps://hdl.handle.net/20.500.14352/104658
dc.issue.number5
dc.journal.titleMycoses
dc.language.isoeng
dc.page.final575
dc.page.initial571
dc.publisherWiley
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu636.09
dc.subject.keywordMalassezia
dc.subject.keywordSusceptibility
dc.subject.keywordTopical antifungals
dc.subject.keywordSystemic antifungals
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleIn vitro antifungal activity of topical and systemic antifungal drugs against Malassezia species
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number56
dspace.entity.typePublication
relation.isAuthorOfPublication62d47891-f33b-4009-a53c-996e05843304
relation.isAuthorOfPublication35bd56d1-9057-441d-a437-50ee7bf6f0b5
relation.isAuthorOfPublication139da539-e06d-4b08-8dd5-b30007394b04
relation.isAuthorOfPublication.latestForDiscovery62d47891-f33b-4009-a53c-996e05843304
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Mycoses - 2013 - Carrillo‐Muñoz.pdf
Size:
101.39 KB
Format:
Adobe Portable Document Format
Description:
In vitro antifungal activity of topical and systemic antifungal drugs against Malassezia species
Download
Collections
Artículos