Antimicrobial sensitisers: Gatekeepers to avoid the development of multidrug-resistant bacteria

Simple item page
dc.contributor.authorWang, Hanfei
dc.contributor.authorYang, Yingying
dc.contributor.authorWang, Simeng
dc.contributor.authorBadawy, Sara
dc.contributor.authorWang, Xu
dc.contributor.authorAres Lombán, Irma
dc.contributor.authorMartínez Caballero, Marta
dc.contributor.authorLópez Torres, Bernardo
dc.contributor.authorMartínez Larrañaga, María Rosa
dc.contributor.authorAnadón Navarro, Arturo Ramón
dc.contributor.authorMartínez Caballero, María Aranzazu
dc.contributor.editorDe Smedt, Stefaan
dc.date.accessioned2024-04-04T16:32:49Z
dc.date.available2024-04-04T16:32:49Z
dc.date.issued2024-03-16
dc.descriptionAuthors contribution: Hanfei Wang: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Yingying Yang: Writing – original draft, Visualization, Supervision, Investigation, Formal analysis, Conceptualization. Simeng Wang: Writing – original draft, Methodology, Investigation, Formal analysis, Conceptualization. Sara Badawy: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Irma Ares: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Marta Martínez: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Bernardo Lopez-Torres: Writing – original draft, Visualization, Supervision, Methodology, Investigation, Formal analysis, Conceptualization. María-Rosa Martínez-Larranaga: ˜ Writing – original draft, Visualization, Supervision, Methodology, Investigation, Formal analysis, Conceptualization. Xu Wang: Writing – review & editing, Writing – original draft, Visualization, Supervision, Project administration, Methodology, Investigation, Formal analysis, Conceptualization. Arturo Anadon: ´ Writing – review & editing, Writing – original draft, Supervision, Project administration, Investigation, Conceptualization. María-Aranzazu ´ Martínez: Writing – review & editing, Writing – original draft, Validation, Supervision, Project administration, Methodology, Investigation, Formal analysis, Conceptualization.
dc.description.abstractThe resistance of multidrug-resistant bacteria to existing antibiotics forces the continued development of new antibiotics and antibacterial agents, but the high costs and long timeframe involved in the development of new agents renders the hope that existing antibiotics may again play a part. The “antibiotic adjuvant” is an indirect antibacterial strategy, but its vague concept has, in the past, limited the development speed of related drugs. In this review article, we put forward an accurate concept of a “non-self-antimicrobial sensitisers (NSAS)”, to distinguish it from an “antibiotic adjuvant”, and then discuss several scientific methods to restore bacterial sensitivity to antibiotics, and the sources and action mechanism of existing NSAS, in order to guide the development and further research of NSAS.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMajor Special Science and Technology Plan (202302AA310020)
dc.description.sponsorshipNational Natural Science Foundation of China (NSFC) (32072925)
dc.description.sponsorshipProject Ref. PID2020-115979RR-C33 from Ministerio de Ciencia e Innovación, Spain (Project/AEI/10.13039/501100011033)
dc.description.statuspub
dc.identifier.doi10.1016/j.jconrel.2024.03.031
dc.identifier.essn1873-4995
dc.identifier.issn0168-3659
dc.identifier.officialurlhttps://www.sciencedirect.com/journal/journal-of-controlled-release
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102719
dc.issue.numberMay 2024
dc.journal.titleJournal of Controlled Release
dc.language.isoeng
dc.page.final38
dc.page.initial25
dc.publisherElsevier
dc.relation.projectIDProject Ref. PID2020-115979RR-C33 from Ministerio de Ciencia e Innovación, Spain (Project/AEI/10.13039/501100011033)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu636.09:615
dc.subject.keywordMultidrug-resistant bacteria
dc.subject.keywordAntibiotic adjuvant
dc.subject.keywordAntimicrobial sensitizer
dc.subject.keywordIndirect antibacterial
dc.subject.ucmFarmacología (Medicina)
dc.subject.unesco3109.08 Farmacología
dc.titleAntimicrobial sensitisers: Gatekeepers to avoid the development of multidrug-resistant bacteria
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number369
dspace.entity.typePublication
relation.isAuthorOfPublication38ae9baa-ab95-45a3-9183-9861451b2c1a
relation.isAuthorOfPublication41bf92b6-7743-40ef-b4b8-ee7a73825cb0
relation.isAuthorOfPublicationa4bd6545-8979-440b-8466-4ae4a0a2956a
relation.isAuthorOfPublicationf9179ac6-e8fa-4628-88ab-59f8114a8fef
relation.isAuthorOfPublication5eeb03dd-21ab-4855-8c05-408d0863bdf4
relation.isAuthorOfPublication72e3a3ef-d7b1-4c63-9ea3-d0d3d543514f
relation.isAuthorOfPublication.latestForDiscovery38ae9baa-ab95-45a3-9183-9861451b2c1a
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Journal_of_Controlled_Release_369_pp_25-38,_2024_.pdf
Size:
4.85 MB
Format:
Adobe Portable Document Format
Description:
Antimicrobial sensitisers: Gatekeepers to avoid the development of multidrug-resistant bacteria
downoload Download
Collections
Artículos