Measurement of Typhim Vi IgG as a Diagnostic Tool to Determine Anti-polysaccharide Antibody Production Deficiency in Children
dc.contributor.author | Guevara-Hoyer, Kissy et al. | |
dc.contributor.author | Pérez de Diego, Rebeca | |
dc.contributor.author | Gil López, Celia | |
dc.contributor.author | Recio Hoyas, María José | |
dc.contributor.author | Fernández Arquero, Miguel | |
dc.contributor.author | Ramos Amador, José Tomás | |
dc.contributor.author | Sánchez Ramón, Silvia María | |
dc.date.accessioned | 2024-01-11T18:05:47Z | |
dc.date.available | 2024-01-11T18:05:47Z | |
dc.date.issued | 2019-04-02 | |
dc.description.abstract | Background: The assessment of specific polysaccharide antibody production plays a pivotal role in the diagnosis of humoral primary immunodeficiencies (PID). The response to 23-valent pneumococcal vaccine (PPV) remains the gold standard for the diagnosis of polysaccharide antibodies. However, in Spain, the interpretation of pure polysaccharide 23-valent immunization is hampered by the high endemicity of pneumococcal disease and the generalization of the 13-valent adjuvant pneumococcal vaccination. Specific Typhim Vi vaccination (TV) immunoglobulin G IgG response to immunization is useful in adult PID, but there is no data regarding children. Objectives: To evaluate the clinical utility of TV IgG production as a diagnostic tool to determine anti-polysaccharide antibody production deficiency in children, when the response to PPV is unclear and isolated determination of serotypes is unfeasible. Methods: We conducted a single-institution prospective observational study on 61 children with recurrent infections. Baseline specific antibodies against PPV and TV were evaluated. In 28 children (46%), the response to the production of antibodies confirmed a clinical suspicion of humoral PID, and they were therefore immunized with 23-valent pneumococcal vaccine and Typhim Vi. Both specific antibody responses were measured by ELISA (The Binding Site Group Ltd, Birmingham, UK) using previously published cut-offs. Results: Seventy percent of the 61 children displayed baseline PPV IgG > 27 mg/L, whereas only 8% showed TV IgG > 28 U/mL (p < 0.0001). Twenty-one of 28 children (75%) achieved a 3-fold increase in post-vaccination TV IgG levels, whereas only 3% achieved a 4-fold increase in PPV IgG post vaccination, mainly due to high baseline PPV IgG titers. When we classified children according to their response to TV as responders or non-responders and compared this with the well-known clinical warning signs of the Jeffrey Modell Foundation. The proportions of children with history of pneumonia and the need for intravenous antibiotics were significantly higher in TV IgG non-responders than in TV IgG responders (p = 0.02 and p = 0.01, respectively). Conclusion: Response to TV can be considered an ancillary diagnostic tool to determine polysaccharide antibodies in children, particularly when isolated determination of pneumococcal serotypes is not feasible. TV provides a useful asset for clinicians in the era of conjugate PPV vaccination, with clinical relevance. Further research is warranted for validation. | |
dc.description.department | Depto. de Inmunología, Oftalmología y ORL | |
dc.description.faculty | Fac. de Medicina | |
dc.description.refereed | TRUE | |
dc.description.status | pub | |
dc.identifier.citation | Guevara-Hoyer K, Gil C, Parker AR, Williams LJ, Orte C, Rodriguez de la Peña A, Ochoa-Grullón J, Rodriguez De Frias E, García IS, García-Gómez S, Recio MJ, Fernández-Arquero M, Pérez de Diego R, Ramos JT, Sánchez-Ramón S. Front Immunol. 2019 Apr 2;10:654. | |
dc.identifier.doi | 10.3389/fimmu.2019.00654 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.officialurl | https://www.frontiersin.org/articles/10.3389/fimmu.2019.00654/full | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/92632 | |
dc.journal.title | Frontiers in Immunology | |
dc.language.iso | eng | |
dc.page.initial | 654 | |
dc.publisher | Frontiers Media S.A | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.cdu | 612.017 | |
dc.subject.keyword | Typhim Vi, , polyssaccharide, vaccine, antibody deficiencies, immunodefiency | |
dc.subject.keyword | Polyssaccharide | |
dc.subject.keyword | Vaccine | |
dc.subject.keyword | Antibody deficiencies | |
dc.subject.keyword | Immunodefiency | |
dc.subject.ucm | Inmunología | |
dc.subject.unesco | 2412 Inmunología | |
dc.title | Measurement of Typhim Vi IgG as a Diagnostic Tool to Determine Anti-polysaccharide Antibody Production Deficiency in Children | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 10 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | b3b3fcb1-0a35-46ce-b7b7-4dc8dc39606a | |
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relation.isAuthorOfPublication | 9ee6ea4a-b0a0-468e-9b6f-21156771b804 | |
relation.isAuthorOfPublication | aa73d86f-18aa-422f-ba37-7e97e4efde5b | |
relation.isAuthorOfPublication | bea59590-c16b-4e29-b8d6-d7b2133b4533 | |
relation.isAuthorOfPublication.latestForDiscovery | b3b3fcb1-0a35-46ce-b7b7-4dc8dc39606a |
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