Evaluation of the Ultrastructural and In Vitro Flow Properties of the PRESERFLO MicroShunt

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dc.contributor.authorIbarz Barberá, Marta
dc.contributor.authorHernández Verdejo, José Luis
dc.contributor.authorBragard, Jean
dc.contributor.authorBurguete, Javier
dc.contributor.authorMorales Fernández, Laura
dc.contributor.authorTañá Rivero, Pedro
dc.contributor.authorGómez de Liaño, Rosario
dc.contributor.authorTeus Guezala, Miguel Ángel
dc.date.accessioned2023-06-16T14:17:40Z
dc.date.available2023-06-16T14:17:40Z
dc.date.issued2021-11-18
dc.descriptionReceived: August 24, 2021 / Accepted: October 21, 2021 / Published: November 18, 2021.
dc.description.abstractPurpose: To measure the in vitro flow properties of the PRESERFLO implant for comparison with the theoretical resistance to flow. Methods: The PRESERFLO was designed to control the flow of aqueous humor according to the Hagen-Poiseuille (HP) equation. Scanning electron microscopy (SEM) was performed to analyze the ultrastructure, and flowmeasurementswere carried out using a gravity-flow setup. Results: SEM images of the PRESERFLO showed luminal diameters of 67.73 × 65.95 μm and 63.66 × 70.54 μm. The total diameter was 337.2 μm, and the wall was 154 μm wide. The theoretical calculation of the resistance to flow(R) for an aqueous humor (AH) viscosity of 0.7185 centipoises (cP) was 1.3 mm Hg/(μL/min). Hence, assuming a constant AH flow of 2 μL/min, the pressure differential across the device (�P) was estimated to be 2.6 mm Hg. The gravity-flow experiment allowed us to measure the experimental resistance to flow, which was RE =1.301mmHg/(μL/min), in agreement with the theoretical resistance to flow R given by the HP equation. Conclusions: The experimental and theoretical flow testing showed that the pressure drop across this device would not be large enough to avoid hypotony unless the resistance to outflowof the sub-Tenon space was sufficient to control the intraocular pressure in the early postoperative period. Translational Relevance: The fluid properties of glaucoma subconjunctival drainage devices determine their specific bleb-forming capacity and ability to avoid hypotony and therefore their safety and efficacy profile.
dc.description.departmentDepto. de Optometría y Visión
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/68964
dc.identifier.doi10.1167/tvst.10.13.26
dc.identifier.issn2164-2591
dc.identifier.officialurlhttps://doi.org/10.1167/tvst.10.13.26
dc.identifier.relatedurlhttp://www.tvstjournal.org/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4558
dc.issue.number13
dc.journal.titleTranslational vision science & technology
dc.language.isoeng
dc.page.initial10 p.
dc.publisherARVO
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.cdu617.7-007.681-089
dc.subject.cdu617.749
dc.subject.cdu612.842.6
dc.subject.keywordPRESERFLO
dc.subject.keywordaqueous flow
dc.subject.keywordpressure drop
dc.subject.keywordglaucoma surgery
dc.subject.keywordHagen-Poiseuille
dc.subject.ucmCirugía
dc.subject.ucmOftalmología
dc.subject.unesco3213 Cirugía
dc.subject.unesco3201.09 Oftalmología
dc.titleEvaluation of the Ultrastructural and In Vitro Flow Properties of the PRESERFLO MicroShunt
dc.typejournal article
dc.volume.number10
dspace.entity.typePublication
relation.isAuthorOfPublication2ed110d3-f335-4688-9c14-1a56e56e8d28
relation.isAuthorOfPublication.latestForDiscovery2ed110d3-f335-4688-9c14-1a56e56e8d28
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