Clinical and microbiological effects of the use of a cetylpyridinium chloride dentifrice and mouth rinse in orthodontic patients: a 3-month randomized clinical trial

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dc.contributor.authorHerrera González, David
dc.contributor.authorEscudero, Nayra
dc.contributor.authorPérez, Leire
dc.contributor.authorOtheo, María
dc.contributor.authorCañete-Sánchez, Elena
dc.contributor.authorPérez Martín, Tania
dc.contributor.authorAlonso Álvarez, Bettina María
dc.contributor.authorSerrano, Jorge
dc.contributor.authorPalma Fernández, Juan Carlos
dc.contributor.authorSanz Alonso, Mariano
dc.contributor.authorMartín, Conchita
dc.date.accessioned2024-02-02T11:41:47Z
dc.date.available2024-02-02T11:41:47Z
dc.date.issued2018-09-28
dc.description.abstractObjective: To assess the clinical, microbiological, and patient-based effects of using a cetylpyridinium chloride (CPC) toothpaste and mouth rinse in orthodontic patients. Design: Parallel randomized controlled, triple-blinded trial (participants, examiners, outcomes' assessors). A computer-generated list was used to allocate treatments. Central allocation was used for concealment. Participants: Thirty-one placebo (10 males, 21 females; mean age 15.2 ± 2.1) and 32 test patients (15 males, 17 females; mean age 15.0 ± 1.8) with fixed orthodontic appliance were included in the study. Interventions: Patients were randomly assigned to both brush and rinse with placebo or with CPC-based products. Products were purposely prepared in white opaque bottles. After screening and professional prophylaxis, patients received a baseline examination, and started to use the assigned products. Patients were monthly assessed during a 3-month period. Main outcome measures: Plaque (PlI) and gingival (GI) indexes. Secondary outcome variables: Calculus index, tooth staining, subgingival microbiological samples, patient-based variables (questionnaire, compliance, and remaining mouth rinse), side-effects (debonded braces or mucosal injuries). Results: Sixty-three patients were randomized, 13 patients were excluded from analysis because of early dropout, leaving 50 patients for intention to treat analysis. PlI in the upper jaw diminished (0.18; SD = 0.82) after 1 month in the test group, while it increased (0.26; SD = 0.62) in the placebo group (P = 0.024). Statistically significant higher GI values were observed in the placebo group at 1 month (mean increase = 0.05; SD = 0.33 versus mean decrease = 0.03; SD = 0.38) and 3 months (mean = 0.05; SD = 0.43 versus mean = 0.02; SD = 0.34). The taste of the test product was rated higher than the placebo at 2- and 3-month visits (P < 0.05). Non-significant changes were observed in microbiological parameters, overgrowth of opportunistic species or remaining secondary outcome variables, including side-effects. Conclusion: The use of CPC-based toothpaste and mouth rinse in orthodontic patients had limited effect in reducing plaque accumulation and gingival inflammation. Effects were little and highly variable. The use of the test products was not associated with relevant adverse effects.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.sponsorshipThis work was partially supported by a research contract between Dentaid (Cerdanyola, Barcelona, Spain) and the University Complutense of Madrid
dc.description.statuspub
dc.identifier.citationHerrera D, Escudero N, Pérez L, Otheo M, Cañete-Sánchez E, Pérez T, Alonso B, Serrano J, Palma JC, Sanz M, Martín C. Clinical and microbiological effects of the use of a cetylpyridinium chloride dentifrice and mouth rinse in orthodontic patients: a 3-month randomized clinical trial. Eur J Orthod. 2018 Sep 28;40(5):465-474
dc.identifier.doi10.1093/ejo/cjx096
dc.identifier.essn1460-2210
dc.identifier.isbn0141-5387
dc.identifier.officialurlhttps://academic.oup.com/ejo/article/40/5/465/4774049?login=true
dc.identifier.pmid29293905
dc.identifier.urihttps://hdl.handle.net/20.500.14352/98214
dc.issue.number5
dc.journal.titleEuropean Journal of Orthodontics
dc.language.isoeng
dc.page.final474
dc.page.initial465
dc.publisherOxford University Press
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616.314
dc.subject.cdu616.314-089.23
dc.subject.cdu615.46
dc.subject.cdu579.61
dc.subject.keywordCalculi
dc.subject.keywordCetylpyridinium
dc.subject.keywordChlorides
dc.subject.keywordDentifrices
dc.subject.keywordGingiva
dc.subject.keywordInsurance
dc.subject.keywordLiability
dc.subject.keywordMaxilla
dc.subject.keywordMouthwash
dc.subject.keywordOrthodontic appliances
dc.subject.keywordTaste perception
dc.subject.keywordTeeth
dc.subject.keywordToothpaste
dc.subject.keywordBraces
dc.subject.keywordMucous membrane
dc.subject.keywordCardiac progenitor cells
dc.subject.keywordOutcome variable
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmOdontología (Odontología)
dc.subject.ucmOrtodoncia
dc.subject.ucmAparatos y material odontológicos
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3213.13 Ortodoncia-Estomatología
dc.subject.unesco3209.03 Evaluación de Medicamentos
dc.titleClinical and microbiological effects of the use of a cetylpyridinium chloride dentifrice and mouth rinse in orthodontic patients: a 3-month randomized clinical trial
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number40
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery92a06fae-e947-48dc-b945-32283225e711
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