Interaction between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers

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dc.contributor.authorNairi, Valentina
dc.contributor.authorMedda, Sara
dc.contributor.authorPiludu, Marco
dc.contributor.authorCasula, Maria Francesca
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.authorMonduzzi, Maura
dc.contributor.authorSalis, Andrea
dc.date.accessioned2023-06-17T12:26:03Z
dc.date.available2023-06-17T12:26:03Z
dc.date.issued2018-01-03
dc.descriptionRESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)
dc.description.abstractBiomedical application of nanoparticles is largely associated to their fate in biological media which, in turn, is related to their surface properties. Surface functionalization plays a key role in determining biodegradation, cytotoxicity and biodistribution through interactions which may be mediated by the macromolecules occurring in biological media. A typical example is given by several proteins which lead to the formation of coated nanoparticles referred as protein corona. In this work we focus on mesoporous silica nanoparticles which, due to their intrinsic textural features, show potential as carriers for sustained drug release. Mesoporous silica nanoparticles functionalized by different biopolymers such as hyaluronic acid and chitosan were synthesized and characterized through small angle X-rays scattering, thermal analysis, and infrared spectroscopy. Biopolymer-coated mesoporous silica nanoparticles were used to investigate the interaction with bovine serum albumin, and to point out the role of different biopolymer coating. Gold-conjugated-bovine serum albumin was used to gain evidence on the occurrence of surface bound proteins enabling direct observation by transmission electron microscopy. Our findings provide insights on how different biopolymers affect the formation of a protein corona around functionalized mesoporous silica nanoparticles.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. FP7
dc.description.sponsorshipFIR 2017, RAS/FdS
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/45941
dc.identifier.doidoi.org/10.1016/j.cej.2018.01.011
dc.identifier.issn1385-8947
dc.identifier.officialurlhttps://www.elsevier.com/
dc.identifier.relatedurlhttp://www.sciencedirect.com/science/article/pii/S1385894718300111
dc.identifier.relatedurlhttp://www.ucm.es/valletregigroup
dc.identifier.urihttps://hdl.handle.net/20.500.14352/11949
dc.journal.titleChemical Engineering Journal
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDCUP F72F16003070002,2017
dc.relation.projectIDVERDI (694160)
dc.rights.accessRightsopen access
dc.subject.cdu546
dc.subject.cdu615.46
dc.subject.keywordMesoporous silica nanoparticles
dc.subject.keywordHyaluronic acid
dc.subject.keywordChitosan
dc.subject.keywordBovine serum albumin
dc.subject.keywordProtein corona
dc.subject.keywordGold nano particles
dc.subject.ucmMateriales
dc.subject.ucmQuímica inorgánica (Química)
dc.subject.unesco3312 Tecnología de Materiales
dc.subject.unesco2303 Química Inorgánica
dc.titleInteraction between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery791023b8-2531-44eb-ba01-56e3b7caa0cb
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