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Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors

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dc.contributor.authorParis, Juan L.
dc.contributor.authorTorre, Paz de la
dc.contributor.authorManzano, Miguel
dc.contributor.authorCabañas Criado, María Victoria
dc.contributor.authorFlores, Ana I.
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2023-06-18T05:43:47Z
dc.date.available2023-06-18T05:43:47Z
dc.date.issued2016-03-15
dc.descriptionRESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) RESEARCHER ID K-3719-2014 (Miguel Manzano García) ORCID 0000-0001-6238-6111 (Miguel Manzano García) RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado) ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)
dc.description.abstractThe potential use of human Decidua-derived mesenchymal stem cells (DMSCs) as a platform to carry mesoporous silica nanoparticles in cancer therapy has been investigated. Two types of nanoparticles were evaluated. The nanoparticles showed negligible toxicity to the cells, a fast uptake and a long retention inside them. Nanoparticle location in the cell was studied by colocalization with the lysosomes. Moreover, the in vitro and in vivo migration of DMSCs towards tumors was not modified by the evaluated nanoparticles. Finally, DMSCs transporting doxorubicin-loaded nanoparticles were capable of inducing cancer cell death in vitro.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipCIBER-BBN
dc.description.sponsorshipAgeing Network of Excellence
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipMMA Foundation
dc.description.sponsorshipParkinson Madrid
dc.description.sponsorshipAccion Estratégica en Salud
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/41725
dc.identifier.doi10.1016/j.actbio.2016.01.017
dc.identifier.issn1742-7061
dc.identifier.urihttps://hdl.handle.net/20.500.14352/23180
dc.journal.titleActa Biomaterialia
dc.language.isospa
dc.page.final282
dc.page.initial275
dc.publisherElsevier
dc.relation.projectIDMAT2012-35556
dc.relation.projectIDCSO2010-11384-E
dc.relation.projectIDMULTIMAT-CHALLENGE (S2013/MIT-2862)
dc.relation.projectIDBES-2013-064182
dc.relation.projectIDFIS PI080137
dc.relation.projectIDPI11/00581
dc.relation.projectIDPI13/00045
dc.relation.projectIDFMMA 2008-108
dc.relation.projectIDPI2012/0032
dc.rights.accessRightsopen access
dc.subject.cdu66
dc.subject.cdu546
dc.subject.cdu615.46
dc.subject.keywordNanoparticles
dc.subject.keywordMesoporous silica
dc.subject.keywordNanomedicine
dc.subject.keywordHuman decidua-derived mesenchymal stem cells
dc.subject.ucmMateriales
dc.subject.ucmQuímica inorgánica (Química)
dc.subject.unesco3312 Tecnología de Materiales
dc.subject.unesco2303 Química Inorgánica
dc.titleDecidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
dc.typejournal article
dc.volume.number33
dspace.entity.typePublication
relation.isAuthorOfPublication516b56e5-68ed-4717-a469-b4380f555994
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery791023b8-2531-44eb-ba01-56e3b7caa0cb

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