Estudios de estabilidad de medicamentos de aplicación en el ámbito hospitalario
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2024
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02/02/2024
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Universidad Complutense de Madrid
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Abstract
La realización de estudios de estabilidad de medicamentos que requieren su adaptación al paciente en el ámbito hospitalario es de gran interés actual ya que interfiere en la organización asistencial de los hospitales y también interfiere en la eficiencia, así como en el gasto económico hospitalario. El objetivo de esta tesis es dar respuesta a la demanda de estos estudios de estabilidad. En concreto, se plantean los estudios de estabilidad de las siguientes preparaciones clínicas elaboradas en los servicios de Farmacia:- Estabilidad de medicamentos de uso hospitalario para tratamiento del cáncer: Estabilidad de bortezomib. La mayoría de los tratamientos oncológicos no disponen de formas farmacéuticas de dosis unitarias adaptadas al pacientes y patología. Es el caso de bortezomib. Además, se ha detectado que la información de estabilidad proporcionada por el fabricante del medicamento reconstituido a la concentración para su administración intravenosa no es homogénea, lo que, sin duda, puede causar gran confusión en la práctica clínica...
The performance of stability studies of drug products that require adaptation to the patient in the hospital setting is of great current interest since it interferes with the organization of hospital care and also interferes with efficiency, as well as with hospital economic expenditure. The aim of this thesis is to respond to the demand for these stability studies. Specifically, stability studies of the following clinical preparations elaborated in the Pharmacy services are proposed:- Stability of drugs for hospital use for cancer treatment: stability of bortezomib. Most oncological treatments do not have unit dose dosage forms adapted to the patient and pathology. This is the case of bortezomib. In addition, it has been detected that the stability information provided by the manufacturer of the reconstituted drug at the concentration for intravenous administration is not homogeneous, which can undoubtedly cause great confusion in clinical practice...
The performance of stability studies of drug products that require adaptation to the patient in the hospital setting is of great current interest since it interferes with the organization of hospital care and also interferes with efficiency, as well as with hospital economic expenditure. The aim of this thesis is to respond to the demand for these stability studies. Specifically, stability studies of the following clinical preparations elaborated in the Pharmacy services are proposed:- Stability of drugs for hospital use for cancer treatment: stability of bortezomib. Most oncological treatments do not have unit dose dosage forms adapted to the patient and pathology. This is the case of bortezomib. In addition, it has been detected that the stability information provided by the manufacturer of the reconstituted drug at the concentration for intravenous administration is not homogeneous, which can undoubtedly cause great confusion in clinical practice...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 02/02/2024