Publication:
Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease

dc.contributor.authorCeprián Costoso, María
dc.contributor.authorFulton, Daniel
dc.date.accessioned2023-06-17T12:35:31Z
dc.date.available2023-06-17T12:35:31Z
dc.date.issued2019-05-17
dc.description.abstractGlia form a central component of the nervous system whose varied activities sustain an environment that is optimised for healthy development and neuronal function. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA)-type glutamate receptors (AMPAR) are a central mediator of glutamatergic excitatory synaptic transmission, yet they are also expressed in a wide range of glial cells where they influence a variety of important cellular functions. AMPAR enable glial cells to sense the activity of neighbouring axons and synapses, and as such many aspects of glial cell development and function are influenced by the activity of neural circuits. However, these AMPAR also render glia sensitive to elevations of the extracellular concentration of glutamate, which are associated with a broad range of pathological conditions. Excessive activation of AMPAR under these conditions may induce excitotoxic injury in glial cells, and trigger pathophysiological responses threatening other neural cells and amplifying ongoing disease processes. The aim of this review is to gather information on AMPAR function from across the broad diversity of glial cells, identify their contribution to pathophysiological processes, and highlight new areas of research whose progress may increase our understanding of nervous system dysfunction and disease.
dc.description.departmentSección Deptal. de Bioquímica y Biología Molecular (Medicina)
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/65881
dc.identifier.doi10.3390/ijms20102450
dc.identifier.issn1422-0067
dc.identifier.officialurlhttps://doi.org/10.3390/ijms20102450
dc.identifier.relatedurlhttps://www.mdpi.com/1422-0067/20/10/2450
dc.identifier.urihttps://hdl.handle.net/20.500.14352/12571
dc.issue.number10
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.page.initial2450
dc.publisherMDPI
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordglia
dc.subject.keywordAMPA receptor
dc.subject.keywordastrocyte
dc.subject.keywordmicroglia
dc.subject.keywordglutamate
dc.subject.keywordexcitotoxicity
dc.subject.keywordinflammation
dc.subject.keywordhypoxia
dc.subject.keywordischemia
dc.subject.keywordmultiple sclerosis
dc.subject.keywordneurodegeneration
dc.subject.ucmMicrobiología médica
dc.subject.unesco3201.03 Microbiología Clínica
dc.titleGlial Cell AMPA Receptors in Nervous System Health, Injury and Disease
dc.typejournal article
dc.volume.number20
dspace.entity.typePublication
relation.isAuthorOfPublicationaf0032f9-2052-4637-acd4-be9b46456a81
relation.isAuthorOfPublication.latestForDiscoveryaf0032f9-2052-4637-acd4-be9b46456a81
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