Double click macrocyclization with Sondheimer diyne of aza-dipyrrins for B–Free bioorthogonal imaging

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dc.contributor.authorWu, Dan
dc.contributor.authorDurán Sampedro, Gonzalo
dc.contributor.authorFitzgerald, Sheila
dc.contributor.authorGarre, Massimiliano
dc.contributor.authorO'Shea, Donal
dc.date.accessioned2024-01-24T09:50:19Z
dc.date.available2024-01-24T09:50:19Z
dc.date.issued2023
dc.description.abstractSequential azide/diyne cycloadditions proved highly effective for the macrocyclization of a bis-azido aza-dipyrrin. Macrocyclic aza-dipyrrin could be produced in 30 min at rt in water with changes in fluorescence intensity and lifetimes measurable upon reaction. Live cell microscopy showed that aza-dipyrrins were suitable for confocal and STED super-resolution imaging and a bioorthogonal response to macrocyclization could be detected in cellular compartments. These results will encourage a broader examination of the sensing and imaging uses of aza-dipyrrins.
dc.description.departmentDepto. de Química Orgánica
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipScience Foundation Ireland
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationWu, Dan, et al. «Double Click Macrocyclization with Sondheimer Diyne of Aza-Dipyrrins for B–F ree Bioorthogonal Imaging». Chemical Communications, vol. 59, n.o 14, 2023, pp. 1951-54. https://doi.org/10.1039/D2CC06461H.
dc.identifier.doi10.1039/d2cc06461h
dc.identifier.essn1364-548X
dc.identifier.issn1359-7345
dc.identifier.officialurlhttps://doi.org/10.1039/D2CC06461H.
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94999
dc.issue.number14
dc.journal.titleChemical Communications
dc.language.isoeng
dc.page.final1954
dc.page.initial1951
dc.publisherRoyal Society of Chemistry
dc.relation.projectID12/RC/2275
dc.relation.projectID18/RI/5723
dc.relation.projectID707618
dc.rights.accessRightsopen access
dc.subject.cdu54
dc.subject.keywordCyclo addition
dc.subject.keywordComplexes
dc.subject.keywordBODIPY
dc.subject.keywordSuper
dc.subject.ucmQuímica
dc.subject.unesco23 Química
dc.titleDouble click macrocyclization with Sondheimer diyne of aza-dipyrrins for B–Free bioorthogonal imaging
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number59
dspace.entity.typePublication
relation.isAuthorOfPublication24ec8912-4d0c-471c-9c44-49d62a79827a
relation.isAuthorOfPublication.latestForDiscovery24ec8912-4d0c-471c-9c44-49d62a79827a

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