Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses

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dc.contributor.authorPérez Carrasco, María Jesús
dc.contributor.authorCarballo Álvarez, Jesús
dc.contributor.authorBarbur, John L.
dc.contributor.authorPuell Marín, María Cinta
dc.dateReceived: April 26, 2021; Accepted: September 13, 2021; Published: October 14, 2021.
dc.date.accessioned2023-06-16T14:16:57Z
dc.date.available2023-06-16T14:16:57Z
dc.date.issued2021-10-14
dc.description.abstractPurpose: Early detection of structural changes in retinal ganglion cells (RGCs) and corresponding changes in visual function is important in early degenerative diseases of the retina, but the sensitivity of both measurements is limited by the inherent variability in healthy subjects. This study investigates the relationships between RGC-related layer thicknesses and foveal and parafoveal flicker modulation sensitivity (FMS) across photopic and mesopic light levels in healthy subjects. Methods: Photopic and mesopic FMS was measured in 56 young adults, at the point of fixation and at an eccentricity of 5 degrees, in each of the four quadrants. Spectraldomain optical coherence tomography (SD-OCT) was used to measure retinal thicknesses. Relationships between foveal and parafoveal FMS and the retinal thickness in the corresponding region were examined after adjusting for confounding variables. Results: Total macular and inner retinal layer (IRL) thicknesses in the parafoveal ring were significant predictors of photopic (P = 0.034) and mesopic (P = 0.034) parafoveal FMS, respectively. The superior peripapillary retinal nerve fiber layer (pRNFL) thickness was a contributing factor to the inferior parafoveal FMS (photopic: P = 0.006 and mesopic: P = 0.021) and the inferior pRNFL thickness was also a contributing factor to the superior parafoveal FMS (photopic: P < 0.001 and mesopic: P = 0.015). Conclusions: The pRNFL thicknesses predict parafoveal FMS for both mesopic and photopic conditions in healthy eyes. Translational Relevance: Themeasurement of rapid flicker sensitivity in the parafoveal retina together with the pRNFL thickness profiles measured before the onset of disease, may provide a more sensitive biomarker for detecting loss of sensitivity caused by the earliest neurodegenerative changes in the eyes.en
dc.description.departmentDepto. de Optometría y Visión
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/68578
dc.identifier.citationPérez Carrasco, M. J., Carballo Álvarez, J., Barbur, J. L., Puell Marín, M. C. Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses». Translational Vision Science & Technology, vol. 10, n.o 12, octubre de 2021, p. 16. DOI.org (Crossref), https://doi.org/10.1167/tvst.10.12.16.
dc.identifier.doi10.1167/tvst.10.12.16
dc.identifier.issn2164-2591
dc.identifier.officialurlhttps://doi.org/10.1167/tvst.10.12.16
dc.identifier.relatedurlhttp://www.tvstjournal.org/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4511
dc.issue.number12
dc.journal.titleTranslational vision science & technology
dc.language.isoeng
dc.page.initial12 p.
dc.publisherARVO
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.cdu617.735-073
dc.subject.cdu617.735-003
dc.subject.cdu611.843
dc.subject.cdu612.843.1
dc.subject.keywordFlicker sensitivity
dc.subject.keywordTemporal contrast sensitivity
dc.subject.keywordRetinal nerve fiber layer (RNFL)
dc.subject.keywordOptical coherence tomography (OCT)
dc.subject.keywordRetinal thickness
dc.subject.ucmOftalmología
dc.subject.ucmOptometría
dc.subject.ucmAnatomía ocular
dc.subject.unesco3201.09 Oftalmología
dc.subject.unesco2209.15 Optometría
dc.titleRelationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknessesen
dc.typejournal article
dc.volume.number10
dspace.entity.typePublication
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relation.isAuthorOfPublicationd90c8dc9-5aef-4047-950e-c6c59469ec3f
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relation.isAuthorOfPublication.latestForDiscoveryd90c8dc9-5aef-4047-950e-c6c59469ec3f
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