Flexible metallic core–shell nanostructured electrodes for neural interfacing

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dc.contributor.authorRodilla González, Beatriz Loreto
dc.contributor.authorArché-Nuñez, Ana
dc.contributor.authorRuiz-Gómez, Sandra
dc.contributor.authorDomínguez-Bajo, Ana
dc.contributor.authorFernández-González, Claudia
dc.contributor.authorGuillén-Colomer, Clara
dc.contributor.authorGonzález-Mayorga, Ankor
dc.contributor.authorRodríguez-Díez, Noelia
dc.contributor.authorCamarero, Julio
dc.contributor.authorMiranda, Rodolfo
dc.contributor.authorLópez-Dolado, Elisa
dc.contributor.authorOcón, Pilar
dc.contributor.authorSerrano, María Concepción
dc.contributor.authorPérez García, Lucas
dc.contributor.authorGonzález, M. Teresa
dc.date.accessioned2024-02-19T19:23:04Z
dc.date.available2024-02-19T19:23:04Z
dc.date.issued2024-02-14
dc.description.abstractElectrodes with nanostructured surface have emerged as promising low-impedance neural interfaces that can avoid the charge‐injection restrictions typically associated to microelectrodes. In this work, we propose a novel approximation, based on a two-step template assisted electrodeposition technique, to obtain flexible nanostructured electrodes coated with core–shell Ni–Au vertical nanowires. These nanowires benefit from biocompatibility of the Au shell exposed to the environment and the mechanical properties of Ni that allow for nanowires longer and more homogeneous in length than their only-Au counterparts. The nanostructured electrodes show impedance values, measured by electrochemical impedance spectroscopy (EIS), at least 9 times lower than those of flat reference electrodes. This ratio is in good accordance with the increased effective surface area determined both from SEM images and cyclic voltammetry measurements, evidencing that only Au is exposed to the medium. The observed EIS profile evolution of Ni–Au electrodes over 7 days were very close to those of Au electrodes and differently from Ni ones. Finally, the morphology, viability and neuronal differentiation of rat embryonic cortical cells cultured on Ni–Au NW electrodes were found to besimilar to those on control (glass) substrates and Au NW electrodes, accompanied by a lower glial cell differentiation. This positive in-vitro neural cell behavior encourages further investigation to explore the tissue responses that the implantation of these nanostructured electrodes might elicit in healthy (damaged) neural tissues in vivo, with special emphasis on eventual tissue encapsulation.
dc.description.departmentDepto. de Física de Materiales
dc.description.facultyFac. de Ciencias Físicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.sponsorshipAgencia Estatal de Investigación (España)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipUnión Europea. Horizonte 2020
dc.description.sponsorshipFondo Europeo de Desarrollo Regional (Unión Europea)
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationRodilla, B.L., Arché-Núñez, A., Ruiz-Gómez, S. et al. Flexible metallic core–shell nanostructured electrodes for neural interfacing. Sci Rep 14, 3729 (2024).
dc.identifier.doi10.1038/s41598-024-53719-4
dc.identifier.essn2045-2322
dc.identifier.officialurlhttps://www.nature.com/articles/s41598-024-53719-4
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101561
dc.journal.titleScientific Reports
dc.language.isoeng
dc.page.final3729-13
dc.page.initial3729-1
dc.publisherSpringer Nature
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-120202RB-I00/ES/NANOMATERIALES INNOVADORES REGENERATIVOS /
dc.relation.projectIDPDC2021-121515-100
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117024GB-C43/ES/NUEVOS MATERIALES PARA UNA CONMUTACION MAGNETICA EFICIENTE EN LA NANOESCALA /
dc.relation.projectIDSEV-2016-0686
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/737116/EU
dc.relation.projectIDS2018/NMT-4321
dc.relation.projectIDS2018/NMT-4291
dc.relation.projectIDCT17/17‐CT18/17
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//CSIC13-4E-1794/ES/Microscopio Electrónico de Barrido de Emisión de Campo (FE-SEM)/
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu538.9
dc.subject.cdu612.8
dc.subject.keywordElectrodeposition
dc.subject.keywordNanostructured electrodes
dc.subject.keywordNeural interfacing
dc.subject.keywordNanotechnology
dc.subject.keywordNeuroscience
dc.subject.ucmFísica de materiales
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.unesco2211 Física del Estado Sólido
dc.subject.unesco2490 Neurociencias
dc.titleFlexible metallic core–shell nanostructured electrodes for neural interfacing
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number14
dspace.entity.typePublication
relation.isAuthorOfPublication2b35287b-53b7-435f-9189-c0c4bf0bd98f
relation.isAuthorOfPublication01b88344-8278-4947-9475-d5b2a652b9d7
relation.isAuthorOfPublication.latestForDiscovery01b88344-8278-4947-9475-d5b2a652b9d7
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