Flexible metallic core–shell nanostructured electrodes for neural interfacing
dc.contributor.author | Rodilla González, Beatriz Loreto | |
dc.contributor.author | Arché-Nuñez, Ana | |
dc.contributor.author | Ruiz-Gómez, Sandra | |
dc.contributor.author | Domínguez-Bajo, Ana | |
dc.contributor.author | Fernández-González, Claudia | |
dc.contributor.author | Guillén-Colomer, Clara | |
dc.contributor.author | González-Mayorga, Ankor | |
dc.contributor.author | Rodríguez-Díez, Noelia | |
dc.contributor.author | Camarero, Julio | |
dc.contributor.author | Miranda, Rodolfo | |
dc.contributor.author | López-Dolado, Elisa | |
dc.contributor.author | Ocón, Pilar | |
dc.contributor.author | Serrano, María Concepción | |
dc.contributor.author | Pérez García, Lucas | |
dc.contributor.author | González, M. Teresa | |
dc.date.accessioned | 2024-02-19T19:23:04Z | |
dc.date.available | 2024-02-19T19:23:04Z | |
dc.date.issued | 2024-02-14 | |
dc.description.abstract | Electrodes with nanostructured surface have emerged as promising low-impedance neural interfaces that can avoid the charge‐injection restrictions typically associated to microelectrodes. In this work, we propose a novel approximation, based on a two-step template assisted electrodeposition technique, to obtain flexible nanostructured electrodes coated with core–shell Ni–Au vertical nanowires. These nanowires benefit from biocompatibility of the Au shell exposed to the environment and the mechanical properties of Ni that allow for nanowires longer and more homogeneous in length than their only-Au counterparts. The nanostructured electrodes show impedance values, measured by electrochemical impedance spectroscopy (EIS), at least 9 times lower than those of flat reference electrodes. This ratio is in good accordance with the increased effective surface area determined both from SEM images and cyclic voltammetry measurements, evidencing that only Au is exposed to the medium. The observed EIS profile evolution of Ni–Au electrodes over 7 days were very close to those of Au electrodes and differently from Ni ones. Finally, the morphology, viability and neuronal differentiation of rat embryonic cortical cells cultured on Ni–Au NW electrodes were found to besimilar to those on control (glass) substrates and Au NW electrodes, accompanied by a lower glial cell differentiation. This positive in-vitro neural cell behavior encourages further investigation to explore the tissue responses that the implantation of these nanostructured electrodes might elicit in healthy (damaged) neural tissues in vivo, with special emphasis on eventual tissue encapsulation. | |
dc.description.department | Depto. de Física de Materiales | |
dc.description.faculty | Fac. de Ciencias Físicas | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Ministerio de Ciencia e Innovación (España) | |
dc.description.sponsorship | Agencia Estatal de Investigación (España) | |
dc.description.sponsorship | Comunidad de Madrid | |
dc.description.sponsorship | Unión Europea. Horizonte 2020 | |
dc.description.sponsorship | Fondo Europeo de Desarrollo Regional (Unión Europea) | |
dc.description.sponsorship | Universidad Complutense de Madrid | |
dc.description.status | pub | |
dc.identifier.citation | Rodilla, B.L., Arché-Núñez, A., Ruiz-Gómez, S. et al. Flexible metallic core–shell nanostructured electrodes for neural interfacing. Sci Rep 14, 3729 (2024). | |
dc.identifier.doi | 10.1038/s41598-024-53719-4 | |
dc.identifier.essn | 2045-2322 | |
dc.identifier.officialurl | https://www.nature.com/articles/s41598-024-53719-4 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/101561 | |
dc.journal.title | Scientific Reports | |
dc.language.iso | eng | |
dc.page.final | 3729-13 | |
dc.page.initial | 3729-1 | |
dc.publisher | Springer Nature | |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-120202RB-I00/ES/NANOMATERIALES INNOVADORES REGENERATIVOS / | |
dc.relation.projectID | PDC2021-121515-100 | |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117024GB-C43/ES/NUEVOS MATERIALES PARA UNA CONMUTACION MAGNETICA EFICIENTE EN LA NANOESCALA / | |
dc.relation.projectID | SEV-2016-0686 | |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/737116/EU | |
dc.relation.projectID | S2018/NMT-4321 | |
dc.relation.projectID | S2018/NMT-4291 | |
dc.relation.projectID | CT17/17‐CT18/17 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CSIC13-4E-1794/ES/Microscopio Electrónico de Barrido de Emisión de Campo (FE-SEM)/ | |
dc.rights | Attribution 4.0 International | en |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.cdu | 538.9 | |
dc.subject.cdu | 612.8 | |
dc.subject.keyword | Electrodeposition | |
dc.subject.keyword | Nanostructured electrodes | |
dc.subject.keyword | Neural interfacing | |
dc.subject.keyword | Nanotechnology | |
dc.subject.keyword | Neuroscience | |
dc.subject.ucm | Física de materiales | |
dc.subject.ucm | Neurociencias (Biológicas) | |
dc.subject.unesco | 2211 Física del Estado Sólido | |
dc.subject.unesco | 2490 Neurociencias | |
dc.title | Flexible metallic core–shell nanostructured electrodes for neural interfacing | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 14 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 2b35287b-53b7-435f-9189-c0c4bf0bd98f | |
relation.isAuthorOfPublication | 01b88344-8278-4947-9475-d5b2a652b9d7 | |
relation.isAuthorOfPublication.latestForDiscovery | 01b88344-8278-4947-9475-d5b2a652b9d7 |