In vivo behavior in rabbit radius bone defect of scaffolds based on nanocarbonate hydroxyapatite

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dc.contributor.authorGarcía Lamas, Lorena
dc.contributor.authorPeña López, Juan
dc.contributor.authorRomán Zaragoza, Jesús
dc.contributor.authorCabañas Criado, María Victoria
dc.contributor.authorBravo Giménez, Beatriz
dc.contributor.authorJiménez Díaz, Verónica
dc.contributor.authorSánchez Salcedo, Sandra
dc.contributor.authorJiménez Holguín, Javier
dc.contributor.authorAbella, Mónica
dc.contributor.authorDesco, Manuel
dc.contributor.authorLozano Borregón, Daniel
dc.contributor.authorCecilia López, David
dc.contributor.authorSalinas Sánchez, Antonio Jesús
dc.date.accessioned2024-02-22T11:36:41Z
dc.date.available2024-02-22T11:36:41Z
dc.date.issued2024-01-12
dc.description.abstractBone defects treatment may require the use of biomaterials that behave as a support and promote bone regeneration. Limitations associated with the use of autografts and allografts make it necessary to design new synthetic bone substitutes. Some of the most promising biomaterials currently under investigation are based on nanocarbonate hydroxyapatite (nCHA). In this study, we studied the bone-inducing capacity of nCHA-based scaffolds alone (SAG) and enriched with osteostatin (SAGO) or with bone marrow aspirate(SAGB) after implantation for 12 weeks in a 15-mm long critical defect performed in the radius of New Zealand rabbits. Bone formation obtained was compared with a group with the unfilled defect (CE), as control group, and other with the defect filed with iliac crest autograft (GS), as gold standard. X-ray follow-up was performed at 2, 4, 6 and 12 weeks and μCT and histological studies at 12 weeks. The radiological results showed a greater increment in bone formation in the GS group (75%–100%), followed by the SAG and SAGB groups (50%–75%). μCT results showed an increase of bone volume/tissue volume values in GS group followed by SAG and SAGB groups (0.53, 0.40, and 0.31 respectively) compared with CE group (0.26). Histological results showed limited resorption of the nCHA scaffolds and partial osseointegration in the SAG and SAGB groups. However, in the SAGO group, the presence of connective tissue encapsulating the scaffold was detected. In SAG, SAGB, and increase of bone formation were observed compared with CE group, but less than the GS group. Thus, the investigated materials represent a significant advance in the design of synthetic materials for bone grafting, but further studies are needed to bring their in vivo behavior closer to autograft, the gold standard.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.statuspub
dc.identifier.doi10.1002/jbm.b.35391
dc.identifier.essn1552-4981
dc.identifier.issn1552-4973
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101661
dc.issue.number112
dc.journal.titleJournal of Biomedical Materials Research Part B: Applied Biomaterials
dc.language.isoeng
dc.page.initial35391
dc.relation.projectIDPDC2021-121656-100
dc.relation.projectIDMCIN/AEI/10.13039/501100011033
dc.relation.projectIDPMPTA22/00121
dc.relation.projectIDPI20/01384
dc.rights.accessRightsopen access
dc.subject.cdu615:54
dc.subject.cdu615.31
dc.subject.keywordBone regeneration
dc.subject.keywordBone substitution
dc.subject.keywordCarbonate hydroxyapatite
dc.subject.keywordCritical defect in radius
dc.subject.keywordNew Zealand rabbit
dc.subject.keywordOsteostatin
dc.subject.keywordScaffolds
dc.subject.ucmQuímica farmaceútica
dc.subject.unesco23 Química
dc.titleIn vivo behavior in rabbit radius bone defect of scaffolds based on nanocarbonate hydroxyapatite
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication
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