A diet supplemented with n-3 polyunsaturated fatty acids influences the metabolic and endocrine response of rabbit does and their offspring

Simple item page
dc.contributor.authorRodríguez, María
dc.contributor.authorGarcía García, Rosa María
dc.contributor.authorArias Álvarez, María
dc.contributor.authorFormoso-Rafferty Castilla, Nora
dc.contributor.authorMillán Pastor, María Pilar
dc.contributor.authorLópez Tello, Jorge
dc.contributor.authorLorenzo González, Pedro Luis
dc.contributor.authorGonzález Bulnes, Antonio
dc.contributor.authorGarcía Rebollar, Pilar
dc.date.accessioned2024-07-01T11:45:50Z
dc.date.available2024-07-01T11:45:50Z
dc.date.issued2017-05-18
dc.description.abstractThe aim of the present study was to evaluate the productive, endocrine, and metabolic responses as well as oxidative stress of rabbit does and their offspring when fed a diet supplemented with n-3 PUFA during their first productive cycle. To this aim, a total of 105 rabbit does were fed ad libitum from d 60 to 172 of age 2 isoenergetic and isoproteic diets differing in fatty acid composition. The control diet (n = 52 does) contained 45.9 g/kg of n-3 of the total fatty acids and the enriched diet (n = 53 does) contained 149.2 g/kg of n-3 of the total fatty acids. Both experimental groups had similar feed intake during rearing, pregnancy, and lactation. The enrichment of diet had no effect on ultrasonographic assessment of does on d 9 and 16 of pregnancy, with an embryonic vesicle number and fetus and placenta size similar between groups (P > 0.05). Even though there were no major effects (P > 0.05) on fertility, duration of gestation, and number born alive and stillborn kits at parturition, live kits from enriched does were longer (71.6 ± 2.42 vs. 79.5 ± 2.13 mm; P < 0.05) and tended to be heavier (42.5 ± 3.94 vs. 50.8 ± 3.47 g; P = 0.07) than those from control does (P < 0.05). The 2 groups had similar milk production and mortality values during lactation; consequently, there were no differences between diets in ADG, litter weight, and number of weaned kits (P > 0.05). In enriched does, higher plasma leptin and estradiol concentrations than in control does (P < 0.05) were observed. In addition, enriched females also had lower total and high-density lipoprotein cholesterol (HDL-c) than control females during lactation (P < 0.05). Regarding offspring, the enrichment of diet with PUFA caused a hyperlipidemic status (greater values of plasma triglycerides, total cholesterol, and HDL-c; P < 0.05) at 1 d postpartum (dpp), compared with the control group, that disappeared at 32 dpp. Supplemented does before parturition and their offspring at 1 dpp had greater oxidative stress than those in the control group. In conclusion, an increase of n-3 PUFA concentration in the diet of rabbit does and, consequently, of their offspring during a productive cycle alters their lipid profile and the indicators of oxidative stress, without major endocrine modifications or improvements in the productive variables.
dc.description.departmentSección Deptal. de Fisiología (Veterinaria)
dc.description.departmentDepto. de Producción Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.identifier.citationRodríguez, M., García-García, R. M., Arias-Álvarez, M., Formoso-Rafferty, N., Millán, P., López-Tello, J., … Rebollar, P. G. (2017). A diet supplemented with -3 polyunsaturated fatty acids influences the metabomscic and endocrine response of rabbit does and their offspring. Journal of Animal Science. Oxford University Press (OUP). http://doi.org/10.2527/jas2017.1429
dc.identifier.doi10.2527/jas2017.1429
dc.identifier.essn1525-3163
dc.identifier.issn0021-8812
dc.identifier.officialurlhttp://doi.org/10.2527/jas2017.1429
dc.identifier.urihttps://hdl.handle.net/20.500.14352/105380
dc.issue.number6
dc.journal.titleJournal of Animal Science
dc.language.isoeng
dc.page.final2700
dc.page.initial2690
dc.publisherOxford University Press
dc.relation.projectIDAGL2011-23822
dc.relation.projectIDS2013/ABI-2913
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu636.09
dc.subject.keywordDocosahexaenoic acid
dc.subject.keywordEicosapentaenoic acid
dc.subject.keywordLeptin
dc.subject.keywordLipid profile
dc.subject.keywordMetabolism
dc.subject.keywordOxidative stress
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleA diet supplemented with n-3 polyunsaturated fatty acids influences the metabolic and endocrine response of rabbit does and their offspring
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number95
dspace.entity.typePublication
relation.isAuthorOfPublication0e188779-5d5d-4ba1-bbf4-e17a29169790
relation.isAuthorOfPublicationf0970140-e003-4813-ba43-d0b7a70fb614
relation.isAuthorOfPublicationc98aa66d-1e7b-4111-a5fc-3ab435cad3b7
relation.isAuthorOfPublication485509ad-ec0b-4e8f-9312-344fdb9a30fa
relation.isAuthorOfPublicationd8062679-e8e0-4135-8730-0d1ad0c60a3d
relation.isAuthorOfPublication.latestForDiscovery0e188779-5d5d-4ba1-bbf4-e17a29169790
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1RodriguezM_JAS_2017_PUFAs.pdf
Size:
1.21 MB
Format:
Adobe Portable Document Format
Description:
A diet supplemented with n-3 polyunsaturated fatty acids influences the metabolic and endocrine response of rabbit does and their offspring
downoload Download
Collections
Artículos