A diet supplemented with n-3 polyunsaturated fatty acids influences the metabolic and endocrine response of rabbit does and their offspring
dc.contributor.author | Rodríguez, María | |
dc.contributor.author | García García, Rosa María | |
dc.contributor.author | Arias Álvarez, María | |
dc.contributor.author | Formoso-Rafferty Castilla, Nora | |
dc.contributor.author | Millán Pastor, María Pilar | |
dc.contributor.author | López Tello, Jorge | |
dc.contributor.author | Lorenzo González, Pedro Luis | |
dc.contributor.author | González Bulnes, Antonio | |
dc.contributor.author | García Rebollar, Pilar | |
dc.date.accessioned | 2024-07-01T11:45:50Z | |
dc.date.available | 2024-07-01T11:45:50Z | |
dc.date.issued | 2017-05-18 | |
dc.description.abstract | The aim of the present study was to evaluate the productive, endocrine, and metabolic responses as well as oxidative stress of rabbit does and their offspring when fed a diet supplemented with n-3 PUFA during their first productive cycle. To this aim, a total of 105 rabbit does were fed ad libitum from d 60 to 172 of age 2 isoenergetic and isoproteic diets differing in fatty acid composition. The control diet (n = 52 does) contained 45.9 g/kg of n-3 of the total fatty acids and the enriched diet (n = 53 does) contained 149.2 g/kg of n-3 of the total fatty acids. Both experimental groups had similar feed intake during rearing, pregnancy, and lactation. The enrichment of diet had no effect on ultrasonographic assessment of does on d 9 and 16 of pregnancy, with an embryonic vesicle number and fetus and placenta size similar between groups (P > 0.05). Even though there were no major effects (P > 0.05) on fertility, duration of gestation, and number born alive and stillborn kits at parturition, live kits from enriched does were longer (71.6 ± 2.42 vs. 79.5 ± 2.13 mm; P < 0.05) and tended to be heavier (42.5 ± 3.94 vs. 50.8 ± 3.47 g; P = 0.07) than those from control does (P < 0.05). The 2 groups had similar milk production and mortality values during lactation; consequently, there were no differences between diets in ADG, litter weight, and number of weaned kits (P > 0.05). In enriched does, higher plasma leptin and estradiol concentrations than in control does (P < 0.05) were observed. In addition, enriched females also had lower total and high-density lipoprotein cholesterol (HDL-c) than control females during lactation (P < 0.05). Regarding offspring, the enrichment of diet with PUFA caused a hyperlipidemic status (greater values of plasma triglycerides, total cholesterol, and HDL-c; P < 0.05) at 1 d postpartum (dpp), compared with the control group, that disappeared at 32 dpp. Supplemented does before parturition and their offspring at 1 dpp had greater oxidative stress than those in the control group. In conclusion, an increase of n-3 PUFA concentration in the diet of rabbit does and, consequently, of their offspring during a productive cycle alters their lipid profile and the indicators of oxidative stress, without major endocrine modifications or improvements in the productive variables. | |
dc.description.department | Sección Deptal. de Fisiología (Veterinaria) | |
dc.description.department | Depto. de Producción Animal | |
dc.description.faculty | Fac. de Veterinaria | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Ministerio de Economía y Competitividad (España) | |
dc.description.sponsorship | Comunidad de Madrid | |
dc.description.status | pub | |
dc.identifier.citation | Rodríguez, M., García-García, R. M., Arias-Álvarez, M., Formoso-Rafferty, N., Millán, P., López-Tello, J., … Rebollar, P. G. (2017). A diet supplemented with -3 polyunsaturated fatty acids influences the metabomscic and endocrine response of rabbit does and their offspring. Journal of Animal Science. Oxford University Press (OUP). http://doi.org/10.2527/jas2017.1429 | |
dc.identifier.doi | 10.2527/jas2017.1429 | |
dc.identifier.essn | 1525-3163 | |
dc.identifier.issn | 0021-8812 | |
dc.identifier.officialurl | http://doi.org/10.2527/jas2017.1429 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/105380 | |
dc.issue.number | 6 | |
dc.journal.title | Journal of Animal Science | |
dc.language.iso | eng | |
dc.page.final | 2700 | |
dc.page.initial | 2690 | |
dc.publisher | Oxford University Press | |
dc.relation.projectID | AGL2011-23822 | |
dc.relation.projectID | S2013/ABI-2913 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.cdu | 636.09 | |
dc.subject.keyword | Docosahexaenoic acid | |
dc.subject.keyword | Eicosapentaenoic acid | |
dc.subject.keyword | Leptin | |
dc.subject.keyword | Lipid profile | |
dc.subject.keyword | Metabolism | |
dc.subject.keyword | Oxidative stress | |
dc.subject.ucm | Veterinaria | |
dc.subject.unesco | 3109 Ciencias Veterinarias | |
dc.title | A diet supplemented with n-3 polyunsaturated fatty acids influences the metabolic and endocrine response of rabbit does and their offspring | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 95 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 0e188779-5d5d-4ba1-bbf4-e17a29169790 | |
relation.isAuthorOfPublication | f0970140-e003-4813-ba43-d0b7a70fb614 | |
relation.isAuthorOfPublication | c98aa66d-1e7b-4111-a5fc-3ab435cad3b7 | |
relation.isAuthorOfPublication | 485509ad-ec0b-4e8f-9312-344fdb9a30fa | |
relation.isAuthorOfPublication | d8062679-e8e0-4135-8730-0d1ad0c60a3d | |
relation.isAuthorOfPublication.latestForDiscovery | 0e188779-5d5d-4ba1-bbf4-e17a29169790 |
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