Probing the effect of the capping polyelectrolyte on the internal structure of Layer-by-Layer decorated nanoliposomes

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dc.contributor.authorMateos-Maroto, Ana
dc.contributor.authorRubio, José
dc.contributor.authorPrévost, Sylvain
dc.contributor.authorMaestro, Armando
dc.contributor.authorGonzález Rubio, Ramón
dc.contributor.authorOrtega Gómez, Francisco
dc.contributor.authorGuzmán Solís, Eduardo
dc.date.accessioned2024-01-24T15:11:11Z
dc.date.available2024-01-24T15:11:11Z
dc.date.issued2023
dc.description.abstractHypothesis The internal organization of polyelectrolyte layers deposited on colloidal templates plays a very important role for the potential applications of these systems as capsules for drug delivery purposes. Experiments The mutual arrangement of oppositely charged polyelectrolyte layers upon their deposition on positively charged liposomes has been studied by combining up three different scattering techniques and Electronic Spin Resonance, which has provided information about the inter-layer interactions and their effect on the final structure of the capsules. Findings The sequential deposition of oppositely charged polyelectrolytes on the external leaflet of positively charged liposomes allows modulating the organization of the obtained supramolecular structures, impacting the packing and rigidity of the obtained capsules due to the change of the ionic cross-linking of the multi-layered film as a result of the specific charge of the last deposited layer. The possibility to modulate the properties of the LbL capsules by tuning the characteristics of the last deposited layers offers a very interesting route for the design of materials for encapsulation purposes with their properties controlled almost at will by changing the number of deposited layers and their chemistry.
dc.description.departmentDepto. de Química Física
dc.description.facultyFac. de Ciencias Químicas
dc.description.facultyInstituto Pluridisciplinar (IP)
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationMateos-Maroto, Ana, et al. «Probing the Effect of the Capping Polyelectrolyte on the Internal Structure of Layer-by-Layer Decorated Nanoliposomes». Journal of Colloid and Interface Science, vol. 640, junio de 2023, pp. 220-29. https://doi.org/10.1016/j.jcis.2023.02.086.
dc.identifier.doi10.1016/j.jcis.2023.02.086
dc.identifier.issn0021-9797
dc.identifier.officialurlhttps://doi.org/10.1016/j.jcis.2023.02.086.
dc.identifier.urihttps://hdl.handle.net/20.500.14352/95163
dc.journal.titleJournal Colloid and Interface Science
dc.language.isoeng
dc.page.final229
dc.page.initial220
dc.publisherElsevier
dc.relation.projectIDPID2019-106557 GB-C21
dc.relation.projectIDEuropean Innovative Training Network-Marie Sklodowska-Curie Action NanoPaInt (grant agreement 955612)
dc.relation.projectIDILL for beamtime allocation of the proposal number 9-13-787 (doi: 10.5291/ILL-DATA.9-13-787).
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu544
dc.subject.ucmQuímica física (Química)
dc.subject.unesco2307 Química Física
dc.subject.unesco2210 Química Física
dc.titleProbing the effect of the capping polyelectrolyte on the internal structure of Layer-by-Layer decorated nanoliposomes
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number15
dspace.entity.typePublication
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