The satiety factor oleoylethanolamide impacts hepatic lipid and glucose metabolism in goldfish

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dc.contributor.authorGómez Boronat, Miguel
dc.contributor.authorVelasco, Cristina
dc.contributor.authorIsorna Alonso, Esther
dc.contributor.authorPedro Ormeño, Nuria de
dc.contributor.authorDelgado Saavedra, María Jesús
dc.contributor.authorSoengas, José L.
dc.date.accessioned2023-06-17T21:54:42Z
dc.date.available2023-06-17T21:54:42Z
dc.date.issued2016-12
dc.description.abstractOleoylethanolamide (OEA) is an acylethanolamide synthesized mainly in the gastrointestinal tract with known effects in mammals on food intake and body mass through activation of peroxisome proliferator-activated receptor type α (PPARα). Since we previously demonstrated that acute treatment with OEA in goldfish resulted in decreased food intake and locomotor activity, as in mammals, we hypothesize that OEA would be involved in the control of energy metabolism in fish. Therefore, we assessed the effects of acute (for 6 h) and chronic (for 11 days) treatments with OEA (5 µg g−1 body mass) on metabolite concentrations and enzyme activities related to glucose and lipid metabolism in liver of goldfish (Carassius auratus). In the chronic treatment, OEA impairs the increase in body mass and reduces locomotor activity, without any signs of stress. The lipolytic capacity in liver decreased after both acute and chronic OEA treatments, whereas lipogenic capacity increased after acute and decreased after chronic treatment with OEA. These results are different from those observed to date in mammalian adipose tissue, but not so different from those known in liver, and might be attributed to the absence of changes in the expression of pparα, and/or to the increase in the expression of the clock gene bmal1a after chronic OEA treatment. As for glucose metabolism, a clear decrease in the capacity of hepatic tissue to use glucose was observed in OEA-treated fish. These results support an important role for OEA in the regulation of liver lipid and glucose metabolism, and could relate to the metabolic changes associated with circadian activity and the regulation of food intake in fish.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipMINECO y Fondo Europeo de Desarrollo Regional
dc.description.sponsorshipUniversidad de Vigo
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/42425
dc.identifier.doi10.1007/s00360-016-1009-x
dc.identifier.issn0174-1578
dc.identifier.officialurlhttps://link.springer.com/journal/360
dc.identifier.urihttps://hdl.handle.net/20.500.14352/17772
dc.issue.number8
dc.journal.titleJournal of Comparative Physiology B
dc.language.isoeng
dc.page.final1021
dc.page.initial1009
dc.publisherSpringer Link
dc.relation.projectIDAGL2013-46448-C3-2-R
dc.relation.projectIDAGL2013-46448-C3-1-R y FEDER
dc.relation.projectIDBES-2014-068103
dc.rights.accessRightsrestricted access
dc.subject.cdu591.1
dc.subject.cdu639.215
dc.subject.keywordOleoylethanolamide (OEA)
dc.subject.keywordGoldfish
dc.subject.keywordLiver
dc.subject.keywordLipid metabolism
dc.subject.keywordGlucose metabolism
dc.subject.keywordBody mass
dc.subject.ucmBiología
dc.subject.ucmFisiología animal (Biología)
dc.subject.ucmPeces
dc.subject.unesco24 Ciencias de la Vida
dc.subject.unesco2401.13 Fisiología Animal
dc.titleThe satiety factor oleoylethanolamide impacts hepatic lipid and glucose metabolism in goldfish
dc.typejournal article
dc.volume.number186
dspace.entity.typePublication
relation.isAuthorOfPublication882d1fb3-a920-418a-9f3f-1b8f6b967032
relation.isAuthorOfPublication48071251-a236-4607-ab33-5332c1472628
relation.isAuthorOfPublication.latestForDiscovery882d1fb3-a920-418a-9f3f-1b8f6b967032
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