Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules.

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dc.contributor.authorCastillo, Rafael R.
dc.contributor.authorLozano Borregón, Daniel
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2023-06-16T15:17:49Z
dc.date.available2023-06-16T15:17:49Z
dc.date.issued2020-05-07
dc.descriptionRESEARCHER ID L-2854-2014 (Rafael Castillo Romero) ORCID 0000-0003-1957-3098 (Rafael Castillo Romero) RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón) ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)
dc.description.abstractThe enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very dièerent nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action. Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. Horizonte 2020
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/60443
dc.identifier.doi10.3390/pharmaceutics12050432
dc.identifier.issn1999-4923
dc.identifier.officialurlhttps://www.mdpi.com/1999-4923/12/5/432
dc.identifier.relatedurlhttps://www.ucm.es/valletregigroup
dc.identifier.urihttps://hdl.handle.net/20.500.14352/6235
dc.issue.number5
dc.journal.titlePharmaceutics
dc.language.isoeng
dc.page.initial432
dc.publisherMDPI
dc.relation.projectIDVERDI (694160)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu543
dc.subject.cdu615.46
dc.subject.keywordMesoporous silica
dc.subject.keywordTherapeutic biomolecules
dc.subject.keywordProteins
dc.subject.keywordPeptides
dc.subject.keywordNucleic acids
dc.subject.keywordGlycans
dc.subject.ucmMateriales
dc.subject.ucmQuímica inorgánica (Farmacia)
dc.subject.unesco3312 Tecnología de Materiales
dc.titleMesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules.
dc.typejournal article
dc.volume.number12
dspace.entity.typePublication
relation.isAuthorOfPublicationbf1fb240-43ed-4474-8dc0-2491074f4ad3
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscoverybf1fb240-43ed-4474-8dc0-2491074f4ad3
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