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A “Janus” face of the RASSF4 signal in cell fate

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dc.contributor.authorLiu, A
dc.contributor.authorZhou, K
dc.contributor.authorMartínez Caballero, María Aranzazu
dc.contributor.authorLópez Torres, Bernardo
dc.contributor.authorMartínez Caballero, Marta
dc.contributor.authorMartínez Larrañaga, María Rosa
dc.contributor.authorWang, X
dc.contributor.authorAnadón Navarro, Arturo Ramón
dc.contributor.authorAres Lombán, Irma
dc.date.accessioned2026-07-17T08:56:42Z
dc.date.available2026-07-17T08:56:42Z
dc.date.issued2021
dc.description.
dc.description.abstractRASSF4 (Ras-association domain family 4) is a protein-coding gene, regarded as a tumor suppressor regulated by DNA methylation. However, RASSF4 acts as a "Janus" in cell fate: death and survival. This review article focuses on the regulatory mechanisms of RASSF4 on cell death and cell survival and puts forward a comprehensive analysis of the relevant signaling pathways. The participation of RASSF4 in the regulation of intracellular store-operated Ca2+ entry also affects cell survival. Moreover, the mechanism of inducing abnormal expression of RASSF4 was summarized. We highlight recent advances in our knowledge of RASSF4 function in the development of cancer and other clinical diseases, which may provide insight into the controversial functions of RASSF4 and its potential application in disease therapy
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipNational Key R & D Program of China
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades ( España)
dc.description.statuspub
dc.identifier.citationLiu, A., Zhou, K., Martínez, M. A., Lopez-Torres, B., Martínez, M., Martínez-Larrañaga, M. R., Wang, X., Anadón, A., & Ares, I. (2022). A "Janus" face of the RASSF4 signal in cell fate. Journal of cellular physiology, 237(1), 466–479. https://doi.org/10.1002/jcp.30592
dc.identifier.doi10.1002/jcp.30592
dc.identifier.essn1097-4652
dc.identifier.issn0021-9541
dc.identifier.officialurlhttps://doi.org/10.1002/jcp.30592
dc.identifier.pmid34553373
dc.identifier.urihttps://hdl.handle.net/20.500.14352/138667
dc.issue.number1
dc.journal.titleJournal of Cellular Physiology
dc.language.isoeng
dc.page.final14
dc.page.initial1
dc.publisherWiley
dc.relation.projectID2018YFC1603005
dc.relation.projectID2662020DKPY020
dc.relation.projectIDPID 2020‐ 115979RR‐C33
dc.rights.accessRightsrestricted access
dc.subject.cdu636.09:615.9
dc.subject.keywordCell death
dc.subject.keywordCell survival
dc.subject.keywordDNA methylation
dc.subject.keywordRASSF4
dc.subject.keywordSignaling pathways
dc.subject.ucmToxicología (Farmacia)
dc.subject.unesco3214 Toxicología
dc.titleA “Janus” face of the RASSF4 signal in cell fate
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number237
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery41bf92b6-7743-40ef-b4b8-ee7a73825cb0

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