Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Markers Expression for Osteoporosis Treatment

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dc.contributor.authorMora Raimundo, Patricia
dc.contributor.authorLozano Borregón, Daniel
dc.contributor.authorManzano García, Miguel
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2023-06-17T13:22:48Z
dc.date.available2023-06-17T13:22:48Z
dc.date.issued2019-05-09
dc.descriptionRESEARCHER ID B-5081-2017 (Daniel Lozano Borregón) ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón) RESEARCHER ID K-3719-2014 (Miguel Manzano García) ORCID 0000-0001-6238-6111 (Miguel Manzano García) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)
dc.description.abstractOsteoporosis is the most common disease involving bone degeneration. Current clinical treatments are not able to offer a satisfying curative effect, so the development of effective treatments is desired. Gene silencing through siRNA delivery has gained great attention as a potential treatment in bone diseases. SOST gene inhibits the Wnt signaling pathway reducing osteoblast differentiation. Consequently, silencing SOST gene with a specific siRNA could be a potential option to treat osteoporosis. Generally, siRNAs have very short half-life and poor transfection capacity, so an effective carrier is needed. In particular, mesoporous silica nanoparticles (MSNs) have attracted great attention for intracellular delivery of nucleic acids. We took advantage of their high loading capacity to further load the pores with osteostatin, an osteogenic peptide. In this study we developed a system based on MSNs coated with poly(ethylenimine), which can effectively deliver SOST siRNA and osteostatin inside cells, with the consequent augmentation of osteogenic markers with a synergistic effect. This established the potential utility of MSNs to co-deliver both biomolecules to promote bone formation, being a potential alternative to treat osteoporosis.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. H2020
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/55253
dc.identifier.doi10.1021/acsnano.9b00241
dc.identifier.issn1936-0851
dc.identifier.officialurlhttps://pubs.acs.org/
dc.identifier.relatedurlhttp://www.ucm.es/valletregigroup
dc.identifier.urihttps://hdl.handle.net/20.500.14352/13303
dc.journal.titleACS Nano
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.projectIDVERDI (694160)
dc.rightsAtribución-NoComercial 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/es/
dc.subject.cdu615.46
dc.subject.cdu546
dc.subject.keywordMesoporous nanoparticles
dc.subject.keywordGene silencing
dc.subject.keywordOsteoporosis
dc.subject.keywordTherapeutic co-delivery
dc.subject.keywordOsteogenic stimulation
dc.subject.ucmMateriales
dc.subject.ucmQuímica inorgánica (Farmacia)
dc.subject.unesco3312 Tecnología de Materiales
dc.titleNanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Markers Expression for Osteoporosis Treatment
dc.typejournal article
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoverybf1fb240-43ed-4474-8dc0-2491074f4ad3
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