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Androgen receptor as prognostic marker in triple-negative breast cancer patients

dc.contributor.authorCabezas Quintario, María Antonia
dc.contributor.authorZenzola, Víctor
dc.contributor.authorArguelles, Miguel
dc.contributor.authorPérez Fernández, Elia
dc.date.accessioned2025-01-28T08:06:13Z
dc.date.available2025-01-28T08:06:13Z
dc.date.issued2018-10-31
dc.description.abstractPurpose: The purpose of this study was to assess the prognostic impact of androgen receptor (AR) expression in patients with triple-negative breast cancer (TNBC). Methods/patients: 101 patients treated for primary TNBC without distant metastasis from 1999 to 2015 were identified from breast surgery database. Kaplan-Meier and Cox regression models evaluated disease-free survival (DFS) and overall survival (OS). Results: AR expression was positive (IHC>1%) in 40% of patients. OS at 36 and 60 months was 86% and 80% in AR-negative patients, and 100% and 96% in AR-positive patients (log rank test 0.036). DFS at 36 and 60 months was 78% and 68% in AR-negative and 92% and 89% in AR-positive (log rank test 0.075). Conclusions: Patients without AR expression have a significant correlation with poor outcome
dc.description.departmentDepto. de Medicina Legal, Psiquiatría y Patología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMA Cabezas-Quintario, V Zenzola, M Arguelles, E Perez-Fernandez. Androgen Receptor as Prognostic Marker in Triple-Negative Breast Cancer Patients. Journal of Medical & Surgical Pathology [Internet]. 2018;03(04). Available from: http://dx.doi.org/10.4172/2472-4971.1000170
dc.identifier.doi10.4172/2472-4971.1000170
dc.identifier.issn2472-4971
dc.identifier.officialurlhttps://doi.org/10.4172/2472-4971.1000170
dc.identifier.relatedurlhttps://www.longdom.org/open-access/androgen-receptor-as-prognostic-marker-in-triplenegative-breast-cancer-patients-2472-4971-1000170.pdf
dc.identifier.relatedurlhttps://www.longdom.org/open-access/androgen-receptor-as-prognostic-marker-in-triplenegative-breast-cancer-patients-42947.html
dc.identifier.urihttps://hdl.handle.net/20.500.14352/116473
dc.issue.number4
dc.journal.titleJournal of Medical & Surgical Pathology
dc.language.isoeng
dc.page.final6
dc.page.initial1
dc.publisherLongdom Group
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu616.1/.9
dc.subject.keywordAndrogen receptor
dc.subject.keywordTriple-negative breast cancer
dc.subject.keywordPrognosis
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmMedicina
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3207 Patología
dc.titleAndrogen receptor as prognostic marker in triple-negative breast cancer patients
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number3
dspace.entity.typePublication

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