Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO-SiO2- P2O5 Glasses in vitro: Insights from Solid-State NMR

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dc.contributor.authorMathew, Renny
dc.contributor.authorTurdean-Ionescu, Claudia
dc.contributor.authorYu, Yang
dc.contributor.authorStevensson, Baltzar
dc.contributor.authorIzquierdo Barba, Isabel
dc.contributor.authorGarcía Fontecha, Ana
dc.contributor.authorArcos Navarrete, Daniel
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.authorEden, Mattias
dc.date.accessioned2023-06-17T21:57:29Z
dc.date.available2023-06-17T21:57:29Z
dc.date.issued2017-05-23
dc.description.abstractWhen exposed to body fluids, mesoporous bioactive glasses (MBGs) of the CaO{SiO2{P2O5 system develop a bone-bonding surface layer that initially consists of amorphous calcium phosphate(ACP), which transforms into hydroxy-carbonate apatite (HCA) with a very similar composition as bone/dentin mineral. Information from various 1H-based solid-state nuclear magnetic resonance (NMR) experiments were combined to elucidate the evolution of the proton speciations both at the MBG surface and within each ACP/HCA constituent of the biomimetic phosphate layer formed when each of three MBGs with distinct Ca, Si, and P contents was immersed in a simulated body fluid (SBF) for variable periods between 15 min and 30 days. Directly excited magic-angle-spinning (MAS) 1H NMR spectra mainly reflect the MBG component, whose surface is rich in water and silanol (SiOH) moieties. Double-quantum{single-quantum correlation 1H NMR experimentation at fast MAS revealed their interatomic proximities. The comparatively minor H species of each ACP and HCA component were probed selectively by heteronuclear 1H{31P NMR experimentation. The initially prevailing ACP phase comprises H2O and "non-apatitic" HPO2.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. FP7
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipSwedish Research Council
dc.description.sponsorshipAgencia Estatal de Investigación (AEI)
dc.description.sponsorshipFondo Europeo de Desarrollo Regional (FEDER)
dc.description.statusinpress
dc.eprint.idhttps://eprints.ucm.es/id/eprint/43067
dc.identifier.issn1932-7447
dc.identifier.officialurlhttp://pubs.acs.org/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/17845
dc.journal.titleJournal of Physical Chemistry C
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.projectIDVERDI (694160)
dc.relation.projectIDMAT 2013-43299-R
dc.relation.projectIDVR-NT 2010-4943
dc.relation.projectID2014- 4667
dc.relation.projectID2015-64831-R
dc.relation.projectID2016-75611-R
dc.rights.accessRightsopen access
dc.subject.cdu546
dc.subject.ucmQuímica inorgánica (Farmacia)
dc.titleProton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO-SiO2- P2O5 Glasses in vitro: Insights from Solid-State NMR
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublicationee9272a2-db11-4efb-97f8-7ce1a18ad55e
relation.isAuthorOfPublication93c09e60-0b6e-49bf-a0aa-bc7a08319f34
relation.isAuthorOfPublicationd92c7075-3d31-45ec-a18d-35a5010ee8e1
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery93c09e60-0b6e-49bf-a0aa-bc7a08319f34
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