Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer

Simple item page
dc.contributor.authorFernández-Marcelo, Tamara
dc.contributor.authorSánchez Pernaute, Andrés
dc.contributor.authorPascua, Irene
dc.contributor.authorJuan Chocano, María Del Carmen De
dc.contributor.authorHead, Jacqueline
dc.contributor.authorTorres García, Antonio José
dc.contributor.authorIniesta Serrano, María Pilar
dc.contributor.editorMichel M Ouellette
dc.date.accessioned2024-01-16T08:43:28Z
dc.date.available2024-01-16T08:43:28Z
dc.date.issued2016-02-25
dc.description.abstractThe role of telomeres and telomerase in colorectal cancer (CRC) is well established as the major driving force in generating chromosomal instability. However, their potential as prognostic markers remains unclear. We investigated the outcome implications of telomeres and telomerase in this tumour type. We considered telomere length (TL), ratio of telomere length in cancer to non-cancer tissue (T/N ratio), telomerase activity and TERT levels; their relation with clinical variables and their role as prognostic markers. We analyzed 132 CRCs and paired non-cancer tissues. Kaplan-Meier curves for disease-free survival were calculated for TL, T/N ratio, telomerase activity and TERT levels. Overall, tumours had shorter telomeres than non-tumour tissues (P < 0.001) and more than 80% of CRCs displayed telomerase activity. Telomere lengths of non-tumour tissues and CRCs were positively correlated (P < 0.001). Considering telomere status and clinical variables, the lowest degree of telomere shortening was shown by tumours located in the rectum (P = 0.021). Regarding prognosis studies, patients with tumours showing a mean TL < 6.35 Kb experienced a significantly better clinical evolution (P < 0.001) and none of them with the highest degree of tumour telomere shortening relapsed during the follow-up period (P = 0.043). The mean TL in CRCs emerged as an independent prognostic factor in the Cox analysis (P = 0.017). Telomerase-positive activity was identified as a marker that confers a trend toward a poor prognosis. In CRC, our results support the use of telomere status as an independent prognostic factor. Telomere status may contribute to explaining the different molecular identities of this tumour type.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipFundación de Investigación Médica Mutua Madrileña
dc.description.sponsorshipBanco Santander
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationFernández-Marcelo T, Sánchez-Pernaute A, Pascua I, De Juan C, Head J, Torres-García A-J, et al. Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer. PLoS ONE 2016;11:e0149626. https://doi.org/10.1371/journal.pone.0149626.
dc.identifier.doi10.1371/journal.pone.0149626
dc.identifier.essn1932-6203
dc.identifier.officialurlhttps://doi.org/10.1371/journal.pone.0149626
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93253
dc.issue.number2
dc.journal.titlePLOS ONE
dc.language.isoeng
dc.page.initiale0149626
dc.page.total12
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu616-006.04
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleClinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication
relation.isAuthorOfPublication64ea548c-394b-4f2a-aeaa-2341b7416dc1
relation.isAuthorOfPublication2a36a0b9-e416-47b7-a6fa-1dd706666732
relation.isAuthorOfPublication790390e8-2a0b-4dca-9996-3e85d11acad7
relation.isAuthorOfPublicationfeb931a4-70c5-4e00-a151-12d4f2573b2c
relation.isAuthorOfPublication.latestForDiscovery64ea548c-394b-4f2a-aeaa-2341b7416dc1
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2016 PLOS ONE 2016 Q1.pdf
Size:
1.76 MB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos