Resistance to Degradation of Silk Fibroin Hydrogels Exposed to Neuroinflammatory Environments

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dc.contributor.authorYonesi, Mahdi
dc.contributor.authorRamos, Milagros
dc.contributor.authorRamírez Castillejo, Carmen
dc.contributor.authorFernández Serra, Rocío
dc.contributor.authorGonzález Nieto, Daniel
dc.contributor.authorPanetsos Petrova, Fivos
dc.contributor.authorBelarra, Adrián
dc.contributor.authorChevalier Del Río, Margarita
dc.contributor.authorRojo, Francisco J.
dc.contributor.authorPérez Rigueiro, José
dc.contributor.authorGuinea, Gustavo V.
dc.date.accessioned2023-11-06T19:10:51Z
dc.date.available2023-11-06T19:10:51Z
dc.date.issued2023-05-28
dc.descriptionThis article belongs to the Special Issue Advanced Biopolymer Materials. Received: 27 March 2023 / Revised: 18 May 2023 / Accepted: 26 May 2023 / Published: 28 May 2023
dc.description.abstractCentral nervous system (CNS) diseases represent an extreme burden with significant social and economic costs. A common link in most brain pathologies is the appearance of inflammatory components that can jeopardize the stability of the implanted biomaterials and the effectiveness of therapies. Different silk fibroin scaffolds have been used in applications related to CNS disorders. Although some studies have analyzed the degradability of silk fibroin in non-cerebral tissues (almost exclusively upon non-inflammatory conditions), the stability of silk hydrogel scaffolds in the inflammatory nervous system has not been studied in depth. In this study, the stability of silk fibroin hydrogels exposed to different neuroinflammatory contexts has been explored using an in vitro microglial cell culture and two in vivo pathological models of cerebral stroke and Alzheimer’s disease. This biomaterial was relatively stable and did not show signs of extensive degradation across time after implantation and during two weeks of in vivo analysis. This finding contrasted with the rapid degradation observed under the same in vivo conditions for other natural materials such as collagen. Our results support the suitability of silk fibroin hydrogels for intracerebral applications and highlight the potentiality of this vehicle for the release of molecules and cells for acute and chronic treatments in cerebral pathologies. © 2023 by the authors.en
dc.description.departmentDepto. de Biodiversidad, Ecología y Evolución
dc.description.departmentDepto. de Radiología, Rehabilitación y Fisioterapia
dc.description.facultyFac. de Óptica y Optometría
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipUnión Europea
dc.description.statuspub
dc.identifier.citationYonesi, M., Ramos, M., Ramírez Castillejo, C. et al. «Resistance to Degradation of Silk Fibroin Hydrogels Exposed to Neuroinflammatory Environments». Polymers, vol. 15, n.o 11, mayo de 2023, p. 2491. DOI.org (Crossref), https://doi.org/10.3390/polym15112491.
dc.identifier.doi10.3390/polym15112491
dc.identifier.issn2073-4360
dc.identifier.officialurlhttps://doi.org/10.3390/polym15112491
dc.identifier.relatedurlhttps://www.mdpi.com/2073-4360/15/11/2491
dc.identifier.urihttps://hdl.handle.net/20.500.14352/88605
dc.issue.number11
dc.journal.titlePolymers
dc.language.isoeng
dc.page.initialart.2491
dc.publisherMDPI
dc.relation.projectIDTHOR, Grant Agreement number 101099719
dc.relation.projectIDS2022/BMD-7236
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116403RB-I00/ES/MODULACION DE LA RESPUESTA A BIOMATERIALES DE TITANIO FUNCIONALIZADOS/
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu546:61
dc.subject.cdu615.46
dc.subject.cdu61:62
dc.subject.keywordAlzheimer’s disease
dc.subject.keywordBrain
dc.subject.keywordDegradation
dc.subject.keywordHydrogels
dc.subject.keywordSilk fibroin
dc.subject.keywordStroke
dc.subject.ucmNeurociencias (Medicina)
dc.subject.ucmMateriales
dc.subject.ucmQuímica orgánica (Química)
dc.subject.unesco2304 Química Macromolecular
dc.subject.unesco2490 Neurociencias
dc.titleResistance to Degradation of Silk Fibroin Hydrogels Exposed to Neuroinflammatory Environmentsen
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number15
dspace.entity.typePublication
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relation.isAuthorOfPublication2e3afff6-4295-44c0-b5e4-67ff4af0ac9e
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relation.isAuthorOfPublication.latestForDiscovery1279018d-18b3-4bb8-b291-d43947d907b2
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