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The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy.

dc.contributor.authorRamos Alonso, Eva
dc.contributor.authorLópez Muñoz, Francisco
dc.contributor.authorGil Martín, Emilio
dc.contributor.authorEgea, Javier
dc.contributor.authorÁlvarez Merz, Iris
dc.contributor.authorPainuli, Sakshi
dc.contributor.authorSemwal, Prabhakar
dc.contributor.authorMartins, Natália
dc.contributor.authorHernández Guijo, Jesús M
dc.contributor.authorRomero Martínez, Manuel Alejandro
dc.date.accessioned2025-05-22T18:26:56Z
dc.date.available2025-05-22T18:26:56Z
dc.date.issued2021-07-20
dc.descriptionAuthor Contributions: Conceptualization, methodology, writing original draft preparation, review and editing, supervision, and funding acquisition, A.R.; writing—review and editing, data curation, and tables, E.R.; review and editing, F.L.-M.; writing—original draft preparation, review and editing, data curation, and visualization, E.G.-M.; review and editing, J.E.; data curation, I.Á.-M.; review and editing and data curation, S.P.; review and editing and data curation, P.S.; conceptualization, writing— original draft preparation and review and editing, N.M.; conceptualization, writing—original draft preparation, review and editing, and supervision, J.M.H.-G. All authors have read and agreed to the published version of the manuscript.
dc.description.abstractViral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, like any other invading microbe, enacts a generalized immune response once the virus contacts the body. Melatonin is a systemic dealer that does not overlook any homeostasis disturbance, which consequently brings into play its cooperative triad, antioxidant, anti-inflammatory, and immune-stimulant backbone, to stop the infective cycle of SARS-CoV-2 or any other endogenous or exogenous threat. In COVID-19, the corporal propagation of SARS-CoV-2 involves an exacerbated oxidative activity and therefore the overproduction of great amounts of reactive oxygen and nitrogen species (RONS). The endorsement of melatonin as a possible protective agent against the current pandemic is indirectly supported by its widely demonstrated beneficial role in preclinical and clinical studies of other respiratory diseases. In addition, focusing the therapeutic action on strengthening the host protection responses in critical phases of the infective cycle makes it likely that multi-tasking melatonin will provide multi-protection, maintaining its efficacy against the virus variants that are already emerging and will emerge as long as SARS-CoV-2 continues to circulate among us.
dc.description.departmentSección Deptal. de Farmacología y Toxicología (Veterinaria)
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipUniversidad Camilo José Cela
dc.description.statuspub
dc.identifier.citationRamos, E., López-Muñoz, F., Gil-Martín, E., Egea, J., Álvarez-Merz, I., Painuli, S., Semwal, P., Martins, N., Hernández-Guijo, J. M., & Romero, A. (2021). The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy. Antioxidants (Basel, Switzerland), 10(7), 1152. https://doi.org/10.3390/antiox10071152
dc.identifier.doi10.3390/antiox10071152
dc.identifier.issn2076-3921
dc.identifier.officialurlhttps://doi.org/10.3390/antiox10071152
dc.identifier.pmid34356384
dc.identifier.urihttps://hdl.handle.net/20.500.14352/120431
dc.issue.number10
dc.journal.titleAntioxidants
dc.language.isoeng
dc.page.initial1152
dc.publisherMDPI
dc.relation.projectIDUCJC 2019-02
dc.relation.projectIDUCJC 2021-21
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu61
dc.subject.keywordSARS-CoV-2
dc.subject.keywordAdjuvant therapy
dc.subject.keywordAntioxidant
dc.subject.keywordCircadian rhythms
dc.subject.keywordClinical trials
dc.subject.keywordInflammation
dc.subject.keywordMelatonin
dc.subject.keywordMitochondria
dc.subject.keywordSafety
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleThe Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy.
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication5f16335c-a2b9-4244-b00f-215f16e7150c
relation.isAuthorOfPublicationc658be58-bda9-4100-ad65-bac31e1256af
relation.isAuthorOfPublication.latestForDiscoveryc658be58-bda9-4100-ad65-bac31e1256af

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