DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition

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dc.contributor.authorMirza-Aghazadeh-Attari, Mohammad
dc.contributor.authorGhazizadeh Darband, Saber
dc.contributor.authorMojtaba Kaviani
dc.contributor.authorSafa, Amin
dc.contributor.authorMihanfar, Ainaz
dc.contributor.authorSadighparvar, Shirin
dc.contributor.authorKarimian, Ansar
dc.contributor.authorAlemi, Forough
dc.contributor.authorMajidinia, Maryam
dc.contributor.authorYousefi, Bahman
dc.contributor.authorRecio Hoyas, María José
dc.date.accessioned2024-01-12T15:02:49Z
dc.date.available2024-01-12T15:02:49Z
dc.date.issued2021-02
dc.description.abstractBreast cancer is the most common and significant cancers in females regarding the loss of life quality. Similar to other cancers, one of the etiologic factors in breast cancer is DNA damage. A plethora of molecules are responsible for sensing DNA damage and mediating actions which lead to DNA repair, senescence, cell cycle arrest and if damage is unbearable to apoptosis. In each of these, aberrations leading to unrepaired damage was resulted in uncontrolled proliferation and cancer. Another cellular function is autophagy defined as a process eliminating of unnecessary proteins in stress cases involved in pathogenesis of cancer. Knowing their role in cancer, scholars have tried to develop strategies in order to target DDR and autophagy. Further, the interactions of DDR and autophagy plus their regulatory role on each other have been focused simultaneously. The present review study has aimed to illustrate the importance of DDR and autophagy in breast cancer according to the related studies and uncover the relation between DDR and autophagy and its significance in breast cancer therapy.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMirza-Aghazadeh-Attari M, Recio MJ, Darband SG, Kaviani M, Safa A, Mihanfar A, Sadighparvar S, Karimian A, Alemi F, Majidinia M, Yousefi B. DNA Repair (Amst). 2021 Feb;98:103032.
dc.identifier.doi10.1016/j.dnarep.2020.103032
dc.identifier.issn1568-7864
dc.identifier.officialurlhttps://www.sciencedirect.com/journal/dna-repair
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92846
dc.journal.titleDNA Repair
dc.language.isoeng
dc.publisherElSEVIER
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu612.017
dc.subject.keywordATG
dc.subject.keywordAutophagy
dc.subject.keywordBeclin-1
dc.subject.keywordBreast cancer
dc.subject.keywordDNA repair
dc.subject.ucmInmunología
dc.subject.unesco2412 Inmunología
dc.titleDNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number98
dspace.entity.typePublication
relation.isAuthorOfPublication436ddd6b-73c0-4f41-9d60-f15490326809
relation.isAuthorOfPublication.latestForDiscovery436ddd6b-73c0-4f41-9d60-f15490326809
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