Increased Levels of Diadenosine Polyphosphates in Dry Eye

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dc.contributor.authorPeral Cerda, María Asunción
dc.contributor.authorCarracedo Rodríguez, Juan Gonzalo
dc.contributor.authorAcosta Boj, María Carmen
dc.contributor.authorGallar Martínez, Juana
dc.contributor.authorPintor Just, Jesús Jerónimo
dc.date.accessioned2023-06-20T11:19:38Z
dc.date.available2023-06-20T11:19:38Z
dc.date.issued2006-09
dc.descriptionEn Open Access en la web del editor
dc.description.abstractPurpose. To analyze the levels of the diadenosine polyphosphates Ap4A and Ap5A in tears, in a set of control subjects and in groups of symptomatic and nonsymptomatic persons with dry eye. Methods. Ninety-seven subjects participated in the study. The subjects were divided into five experimental groups: control subjects; symptomatic patients with normal tear secretion; symptomatic patients with low tear secretion; forced blink; and corneal mechanical stimulation provided by a gas esthesiometer. The Schirmer I test was used to measure and collect tear secretions from each subject. All samples were processed by high pressure liquid chromatography (HPLC) and their Ap4A and Ap5A levels determined. Results. The levels of Ap4A and Ap5A in tears were greater in all symptomatic patients than in control subjects, especially in symptomatic subjects with low tear secretion. Within the symptomatic subjects with normal tear secretion, significant differences in concentrations of Ap4A and Ap5A were found between men and women. In the forced blink experiments, concentrations of the Ap4A and Ap5A rose with increasing blink frequency. When the cornea was mechanically stimulated, the levels of Ap4A and Ap5A rose significantly during both moderate and high-flow rate tests. Conclusions. The increased levels of Ap4A and Ap5A in tears of patients with dry eye allow these dinucleotides to be used as objective biomarkers in dry eye conditions.en
dc.description.departmentDepto. de Optometría y Visión
dc.description.departmentUnidad Docente de Bioquímica y Biología Molecular
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/39564
dc.identifier.citationPeral Cerda, M. A., Carracedo Rodríguez, J. G., Acosta Boj, M. C. et al. «Increased Levels of Diadenosine Polyphosphates in Dry Eye». Investigative Opthalmology & Visual Science, vol. 47, n.o 9, septiembre de 2006, p. 4053. DOI.org (Crossref), https://doi.org/10.1167/iovs.05-0980.
dc.identifier.doi10.1167/iovs.05-0980
dc.identifier.issn0146-0404
dc.identifier.officialurlhttp://dx.doi.org/10.1167/iovs.05-0980
dc.identifier.relatedurlhttp://iovs.arvojournals.org/article.aspx?articleid=2163790&resultClick=1
dc.identifier.urihttps://hdl.handle.net/20.500.14352/51961
dc.issue.number9
dc.journal.titleInvestigative Ophthalmology & Visual Science
dc.language.isoeng
dc.page.final4058
dc.page.initial4053
dc.publisherThe Association for Research in Vision and Ophthalmology, Inc.
dc.relation.projectIDCENIT (Nanofarma)
dc.relation.projectIDSAF2005-07277
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.cdu577.15
dc.subject.cdu617.764
dc.subject.keywordBodily secretions
dc.subject.keywordDiadenosine poliphosphates
dc.subject.keywordDry eye
dc.subject.ucmBioquímica (Química)
dc.subject.ucmOftalmología
dc.subject.ucmAnatomía ocular
dc.subject.unesco3201.09 Oftalmología
dc.titleIncreased Levels of Diadenosine Polyphosphates in Dry Eyeen
dc.typejournal article
dc.volume.number47
dspace.entity.typePublication
relation.isAuthorOfPublication2b3052fa-b98a-44f3-a982-f01bccb83c6a
relation.isAuthorOfPublication97433353-d31b-4cf5-b2c0-47d2e6703fe5
relation.isAuthorOfPublicatione8366c14-6aee-427c-8601-f6bf1e360010
relation.isAuthorOfPublication.latestForDiscovery97433353-d31b-4cf5-b2c0-47d2e6703fe5
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