A Low Number of Baselines γδ T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection

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dc.contributor.authorAndreu-Ballester, Juan Carlos
dc.contributor.authorGalindo-Regal, Lorena
dc.contributor.authorCuéllar Del Hoyo, María Del Carmen
dc.contributor.authorLópez-Chuliá, Francisca
dc.contributor.authorGarcía-Ballesteros, Carlos
dc.contributor.authorFernández-Murga, Leonor
dc.contributor.authorLlombart-Cussac, Antonio
dc.contributor.authorDomínguez-Márquez, María Victoria
dc.contributor.editorKlasse, P. J.
dc.contributor.editorMostafa, Mai
dc.date.accessioned2024-07-17T11:36:49Z
dc.date.available2024-07-17T11:36:49Z
dc.date.issued2024-05-18
dc.description.abstractBackground: The COVID-19 pandemic is the biggest global health problem in the last hundred years. The efficacy of the vaccine to protect against severe disease is estimated to be 70–95% according to the studies carried out, although there are aspects of the immune response to the vaccine that remain unclear. Methods: Humoral and cellular immunity after the administration of three doses of the Pfizer–BioNTech and Oxford AstraZeneca vaccines against SARS-CoV-2 over one year and the appearance of post-vaccination COVID-19 were studied. SARS-CoV-2 IgG and IgA antibodies, αβ and γδ T-cell subsets, and their differentiation stages and apoptosis were analyzed. Results: Anti-SARS-CoV-2 IgG and IgA antibodies showed a progressive increase throughout the duration of the study. This increase was the greatest after the third dose. The highest levels were observed in subjects who had anti-SARS-CoV-2 antibodies prior to vaccination. There was an increase in CD4+ αβ, CD8+ γδ and TEM CD8+ γδ T cells, and a decrease in apoptosis in CD4+ CD8+ and CD56+ αβ and γδ T cells. Post-vaccination SARS-CoV-2 infection was greater than 60%. The symptoms of COVID-19 were very mild and were related to a γδ T cell deficit, specifically CD8+ TEMRA and CD56+ γδ TEM, as well as lower pre-vaccine apoptosis levels. Conclusions: The results unveil the important role of γδ T cells in SARS-CoV-2-vaccine-mediated protection from the disease.
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.fundingtypePagado por el autor
dc.description.refereedTRUE
dc.description.sponsorshipREACT-EU programme
dc.description.sponsorshipConsellería de Sanitat Universal i Salut Pública (Generalitat Valenciana, Spain)
dc.description.statuspub
dc.identifier.citationAndreu-Ballester, Juan Carlos, et al. «A Low Number of Baselines Γδ T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection». Vaccines, vol. 12, n.o 5, mayo de 2024, p. 553. www.mdpi.com, https://doi.org/10.3390/vaccines12050553.
dc.identifier.doi10.3390/vaccines12050553
dc.identifier.issn2076-393X
dc.identifier.officialurlhttps://www.mdpi.com/2076-393X/12/5/553
dc.identifier.urihttps://hdl.handle.net/20.500.14352/106814
dc.issue.number5
dc.journal.titleVaccines (Basel)
dc.language.isoeng
dc.page.initial553
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu579.6
dc.subject.cdu615.28
dc.subject.cdu576.8
dc.subject.keywordSARS-CoV-2
dc.subject.keywordvaccine
dc.subject.keywordantibodies
dc.subject.keywordαβ T cells
dc.subject.keywordγδ T cells
dc.subject.ucmMicrobiología (Farmacia)
dc.subject.ucmParasitología (Farmacia)
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3207.12 Parasitología
dc.titleA Low Number of Baselines γδ T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication
relation.isAuthorOfPublication6c555fb4-e29c-4463-8062-a9699fcebaa6
relation.isAuthorOfPublication.latestForDiscovery6c555fb4-e29c-4463-8062-a9699fcebaa6
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