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Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

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dc.contributor.authorMoreno, Estefanía
dc.contributor.authorAndradas, Clara
dc.contributor.authorMedrano, Mireia
dc.contributor.authorCaffarel, María M.
dc.contributor.authorBlasco-Benito, Sandra
dc.contributor.authorPazos, M. Ruth
dc.contributor.authorIrving, Andrew J.
dc.contributor.authorLluís, Carme
dc.contributor.authorCanela, Enric I.
dc.contributor.authorMcCormick, Peter J.
dc.contributor.authorGómez Cañas, María
dc.contributor.authorPérez Gómez, Eduardo
dc.contributor.authorFernández Ruiz, José Javier
dc.contributor.authorGuzmán Pastor, Manuel
dc.contributor.authorSánchez García, María Cristina
dc.date.accessioned2024-01-16T15:31:24Z
dc.date.available2024-01-16T15:31:24Z
dc.date.issued2014-08
dc.description.abstractThe G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMoreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI,Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C. Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling. J Biol Chem. 2014, 289(32):21960-72.
dc.identifier.issn0021-9258
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0021925820331367?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93416
dc.issue.number32
dc.journal.titleTHE JOURNAL OF BIOLOGICAL CHEMISTRY
dc.language.isoeng
dc.page.final21972
dc.page.initial21960
dc.publisherElsevier
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu577.1
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleTargeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number289
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery4603fb50-fc50-4d17-a7fb-dc93ee96609c

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