Cannabinoid signalling in the immature brain: Encephalopathies and neurodevelopmental disorders
dc.contributor.author | Sagredo Ezquioga, Onintza | |
dc.contributor.author | Palazuelos Diego, Javier | |
dc.contributor.author | Gutierrez-Rodriguez, Ana | |
dc.contributor.author | Satta, Valentina | |
dc.contributor.author | Galve Roperh, Ismael | |
dc.contributor.author | Martínez Orgado, José Antonio | |
dc.date.accessioned | 2023-11-27T15:39:34Z | |
dc.date.available | 2023-11-27T15:39:34Z | |
dc.date.issued | 2018-08-15 | |
dc.description.abstract | The endocannabinoid system exerts a crucial neuromodulatory role in many brain areas that is essential for proper regulation of neuronal activity. The role of cannabinoid signalling controlling neuronal activity in the adult brain is also evident when considering its contribution to adult brain insults or neurodegenerative diseases. In the context of brain genetic or acquired encephalopathies administration of cannabinoid-based molecules has demonstrated to exert symptomatic relief and hence, they are proposed as new potential therapeutic compounds. This review article summarizes the main evidences indicating the beneficial action of cannabinoid-derived molecules in preclinical models of neonatal hypoxia/ischemic damage. In a second part, we discuss the available evidences of therapeutic actions of cannabidiol in children with refractory epilepsy syndromes. Finally, we discuss the current view of cannabinoid signalling mechanisms active in the immature brain that affect in neural cell fate and can contribute to long-term neural cell plasticity. | |
dc.description.department | Depto. de Bioquímica y Biología Molecular | |
dc.description.faculty | Fac. de Ciencias Biológicas | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Ministerio de Economía y Competitividad (MINECO)/Fondo Europeo de desarrollo Regional (FEDER) | |
dc.description.sponsorship | Comunidad de Madrid | |
dc.description.sponsorship | Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional (FEDER) | |
dc.description.sponsorship | GW Research Ltd | |
dc.description.sponsorship | Universidad Complutense de Madrid (UCM)/Banco de Santander | |
dc.description.status | pub | |
dc.identifier.doi | 10.1016/j.bcp.2018.08.014 | |
dc.identifier.issn | 0006-2952 | |
dc.identifier.officialurl | https://www.sciencedirect.com/science/article/pii/S0006295218303344 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/88996 | |
dc.issue.number | 157 | |
dc.journal.title | Biochemical Pharmacology | |
dc.language.iso | eng | |
dc.page.final | 96 | |
dc.page.initial | 85 | |
dc.publisher | Elsevier | |
dc.relation.projectID | (RTC-2015-3364-1 and SAF2017-83516-R) | |
dc.relation.projectID | (S2010/BMD-2308) (2016-T1-/BMD-1060, Atracción de Talento) | |
dc.relation.projectID | (#PI15-0310; Plan Estatal de I+D+i 2013-2016; FIS-PS1600629; CB06/05/0089) | |
dc.relation.projectID | (GWCRI09119) | |
dc.rights.accessRights | restricted access | |
dc.subject.cdu | 615.9 | |
dc.subject.cdu | 612.8 | |
dc.subject.keyword | Endocannabinoid system | |
dc.subject.keyword | Hypoxia/ischemia | |
dc.subject.keyword | Refractory epilepsy | |
dc.subject.keyword | Cannabidiol | |
dc.subject.keyword | Neurogenesis | |
dc.subject.keyword | Neurodevelopment | |
dc.subject.ucm | Bioquímica (Biología) | |
dc.subject.ucm | Neurociencias (Biológicas) | |
dc.subject.unesco | 2403 Bioquímica | |
dc.subject.unesco | 2490 Neurociencias | |
dc.title | Cannabinoid signalling in the immature brain: Encephalopathies and neurodevelopmental disorders | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 2018 | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication | 03162d7f-e1e1-4b51-b7ec-e20adaf7c220 | |
relation.isAuthorOfPublication.latestForDiscovery | 65303cb3-2a8a-420a-8bdf-ae20646fc847 |
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