Cannabinoid signalling in the immature brain: Encephalopathies and neurodevelopmental disorders

Simple item page
dc.contributor.authorSagredo Ezquioga, Onintza
dc.contributor.authorPalazuelos Diego, Javier
dc.contributor.authorGutierrez-Rodriguez, Ana
dc.contributor.authorSatta, Valentina
dc.contributor.authorGalve Roperh, Ismael
dc.contributor.authorMartínez Orgado, José Antonio
dc.date.accessioned2023-11-27T15:39:34Z
dc.date.available2023-11-27T15:39:34Z
dc.date.issued2018-08-15
dc.description.abstractThe endocannabinoid system exerts a crucial neuromodulatory role in many brain areas that is essential for proper regulation of neuronal activity. The role of cannabinoid signalling controlling neuronal activity in the adult brain is also evident when considering its contribution to adult brain insults or neurodegenerative diseases. In the context of brain genetic or acquired encephalopathies administration of cannabinoid-based molecules has demonstrated to exert symptomatic relief and hence, they are proposed as new potential therapeutic compounds. This review article summarizes the main evidences indicating the beneficial action of cannabinoid-derived molecules in preclinical models of neonatal hypoxia/ischemic damage. In a second part, we discuss the available evidences of therapeutic actions of cannabidiol in children with refractory epilepsy syndromes. Finally, we discuss the current view of cannabinoid signalling mechanisms active in the immature brain that affect in neural cell fate and can contribute to long-term neural cell plasticity.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)/Fondo Europeo de desarrollo Regional (FEDER)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipInstituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional (FEDER)
dc.description.sponsorshipGW Research Ltd
dc.description.sponsorshipUniversidad Complutense de Madrid (UCM)/Banco de Santander
dc.description.statuspub
dc.identifier.doi10.1016/j.bcp.2018.08.014
dc.identifier.issn0006-2952
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0006295218303344
dc.identifier.urihttps://hdl.handle.net/20.500.14352/88996
dc.issue.number157
dc.journal.titleBiochemical Pharmacology
dc.language.isoeng
dc.page.final96
dc.page.initial85
dc.publisherElsevier
dc.relation.projectID(RTC-2015-3364-1 and SAF2017-83516-R)
dc.relation.projectID(S2010/BMD-2308) (2016-T1-/BMD-1060, Atracción de Talento)
dc.relation.projectID(#PI15-0310; Plan Estatal de I+D+i 2013-2016; FIS-PS1600629; CB06/05/0089)
dc.relation.projectID(GWCRI09119)
dc.rights.accessRightsrestricted access
dc.subject.cdu615.9
dc.subject.cdu612.8
dc.subject.keywordEndocannabinoid system
dc.subject.keywordHypoxia/ischemia
dc.subject.keywordRefractory epilepsy
dc.subject.keywordCannabidiol
dc.subject.keywordNeurogenesis
dc.subject.keywordNeurodevelopment
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.unesco2403 Bioquímica
dc.subject.unesco2490 Neurociencias
dc.titleCannabinoid signalling in the immature brain: Encephalopathies and neurodevelopmental disorders
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number2018
dspace.entity.typePublication
relation.isAuthorOfPublication65303cb3-2a8a-420a-8bdf-ae20646fc847
relation.isAuthorOfPublication40a55557-1c65-4708-bb50-9ddff8f0bf25
relation.isAuthorOfPublication5c2f6328-59fa-408b-b95f-30e6fed1a0d4
relation.isAuthorOfPublication8c2a1d13-f2a3-4355-8b66-73e0f97c0cea
relation.isAuthorOfPublication03162d7f-e1e1-4b51-b7ec-e20adaf7c220
relation.isAuthorOfPublication.latestForDiscovery65303cb3-2a8a-420a-8bdf-ae20646fc847
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Sagredo et al., 2018.pdf
Size:
521.54 KB
Format:
Adobe Portable Document Format
Download
Collections
Artículos