Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy

Simple item page
dc.contributor.authorFernández-Nogueira, Patricia
dc.contributor.authorMancino, Mario
dc.contributor.authorFuster, Gemma
dc.contributor.authorBragado Domingo, Paloma
dc.contributor.authorPrats de Puig, Miquel
dc.contributor.authorGascón, Pere
dc.contributor.authorCasado, Francisco Javier
dc.contributor.authorCarbó, Neus
dc.date.accessioned2023-06-17T09:10:20Z
dc.date.available2023-06-17T09:10:20Z
dc.date.issued2020-03-12
dc.description.abstractCurrent evidences state clear that both normal development of breast tissue as well as its malignant progression need many-sided local and systemic communications between epithelial cells and stromal components. During development, the stroma, through remarkably regulated contextual signals, affects the fate of the different mammary cells regarding their specification and differentiation. Likewise, the stroma can generate tumour environments that facilitate the neoplastic growth of the breast carcinoma. Mammographic density has been described as a risk factor in the development of breast cancer and is ascribed to modifications in the composition of breast tissue, including both stromal and glandular compartments. Thus, stroma composition can dramatically affect the progression of breast cancer but also its early detection since it is mainly responsible for the differences in mammographic density among individuals. This review highlights both the pathological and biological evidences for a pivotal role of the breast stroma in mammographic density, with particular emphasis on dense and malignant stromas, their clinical meaning and potential therapeutic implications for breast cancer patients.
dc.description.departmentSección Deptal. de Bioquímica y Biología Molecular (Farmacia)
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipBBVA
dc.description.sponsorshipSecretaria d’Universitats i Recerca del Departament d’Economia i Coneixement
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/67127
dc.identifier.doi10.3390/jcm9030776
dc.identifier.issn2077-0383
dc.identifier.officialurlhttps://doi.org/10.3390/jcm9030776
dc.identifier.relatedurlhttps://www.mdpi.com/2077-0383/9/3/776
dc.identifier.urihttps://hdl.handle.net/20.500.14352/8322
dc.issue.number3
dc.journal.titleJournal of Clinical Medicine
dc.language.isoeng
dc.page.initial776
dc.publisherMDPI
dc.relation.projectIDBBM-TRA-0041 (Becas Leonardo)
dc.relation.projectID2017_SGR_1305
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordtumour stroma
dc.subject.keywordmammographic density
dc.subject.keywordtherapy resistance
dc.subject.keywordductal carcinoma in situ (DCIS)
dc.subject.keywordinvasive ductal carcinoma (IDC)
dc.subject.keywordbreast cancer detection
dc.subject.ucmAnálisis clínicos
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.ucmBioquímica (Farmacia)
dc.titleBreast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy
dc.typejournal article
dc.volume.number9
dspace.entity.typePublication
relation.isAuthorOfPublicationaf6d6daf-5919-4e1c-b9e5-bb496fa46397
relation.isAuthorOfPublication.latestForDiscoveryaf6d6daf-5919-4e1c-b9e5-bb496fa46397
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jcm-09-00776-v3.pdf
Size:
1.49 MB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos