Influence of the Human Development Index on the Maternal–Perinatal Morbidity and Mortality of Pregnant Women with SARS-CoV-2 Infection: Importance for Personalized Medical Care

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dc.contributor.authorCuñarro López, Yolanda
dc.contributor.authorGarcia Tizon Larroca, Santiago
dc.contributor.authorPintado Recarte, Pilar
dc.contributor.authorHernández Martín, Concepción
dc.contributor.authorPrats Rodríguez, Pilar
dc.contributor.authorCano Valderrama, Óscar
dc.contributor.authorCueto Hernández, Ignacio
dc.contributor.authorRuiz Labarta, Javier
dc.contributor.authorMuñóz Chápuli, María del Mar
dc.contributor.authorMartínez Pérez, Óscar
dc.contributor.authorOrtega, Miguel Angel
dc.contributor.authorDe León Luis, Juan Antonio
dc.date.accessioned2023-06-16T14:26:35Z
dc.date.available2023-06-16T14:26:35Z
dc.date.issued2021-08-17
dc.descriptionThis study (FIS-PI18/00912) was supported by the Instituto de Salud Carlos III (Plan Estatal de I + D + i 2013–2016) and cofinanced by the European Development Regional Fund ‘‘A way to achieve Europe’’ (ERDF) and B2017/BMD-3804 MITIC-CM.en
dc.description.abstractCoronavirus disease-19 (COVID-19) is perhaps the most worrisome pandemic in the 21st century, having entailed devastating consequences for the whole society during the last year. Different studies have displayed an existing association between pregnancy and COVID-19 severity due to the various physiological changes that occur during gestation. Recent data identified maternal country of origin as an important determinant of COVID-19 presentation in pregnant women. However, the explanation of this fact remains to be fully elucidated. Therefore, the purpose of this work is to analyze the possible relationship between Human Development Index (HDI) of maternal country of origin with the morbimortality of pregnant women and their newborns. Here, we conducted a multicentric, ambispective, observational case-control study (1:1 ratio) and compare with the HDI of each country (group 1—very high HDI, group 2—high HDI, group 3—medium HDI, and group 4—low HDI). In total, 1347 pregnant women with confirmed SARV-CoV-2 infection (cases) were enrolled, and each was paired with one control to give a total number of 2694 participants from 81 tertiary care centers. Among the women with SARS-CoV-2 infection, more cases were produced of perinatal mortality, overall maternal morbidity, COVID-19 maternal morbidity, C-sections, hypertensive maternal morbidity, and perinatal morbidity. Our results described an inverse association between HDI and maternofetal morbidity and mortality. Moreover, the countries with an HDI lower than 1 showed higher rates of patients with maternal COVID-19-related morbidity (6.0% vs. 2.4%, p < 0.001), a need for oxygen therapy (4.7% vs. 1.8%, p < 0.001), and maternal ICU admission (2.6% vs. 1.0%, p = 0.007). Compared to other risk factors such as overweight, obesity, preexisting and obstetric comorbidities, HDI emerged as an independent risk factor explaining much of the increased maternal–perinatal morbidity and mortality detected in our group of cases. Further research is needed to establish to confirm the real impact of this factor and its components on pregnancy outcomes.en
dc.description.departmentDepto. de Salud Pública y Materno - Infantil
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/77627
dc.identifier.citationCuñarro-López Y, Larroca SG-T, Pintado-Recarte P, Hernández-Martín C, Prats-Rodríguez P, Cano-Valderrama Ó, et al. Influence of the Human Development Index on the Maternal–Perinatal Morbidity and Mortality of Pregnant Women with SARS-CoV-2 Infection: Importance for Personalized Medical Care. JCM 2021;10:3631. https://doi.org/10.3390/jcm10163631.
dc.identifier.doi10.3390/jcm10163631
dc.identifier.issn2077-0383
dc.identifier.officialurlhttps://doi.org/10.3390/jcm10163631
dc.identifier.relatedurlhttps://www.mdpi.com/2077-0383/10/16/3631
dc.identifier.urihttps://hdl.handle.net/20.500.14352/5043
dc.issue.number16
dc.journal.titleJournal of Clinical Medicine
dc.language.isoeng
dc.page.initial3631
dc.publisherMDPI
dc.relation.projectIDFEDER
dc.relation.projectIDB2017/BMD-3804 MITIC-CM
dc.relation.projectIDPlan Estatal de I + D + i 2013–2016 (FIS-PI18/00912)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu618.2
dc.subject.cdu616.9
dc.subject.keywordCoronavirus disease-19 (COVID-19)
dc.subject.keywordPregnancy
dc.subject.keywordHuman development index (HDI)
dc.subject.keywordMaternal–perinatal outcomes
dc.subject.keywordMaternal–perinatal morbidity and mortality
dc.subject.ucmMedicina
dc.subject.ucmEnfermedades infecciosas
dc.subject.ucmGinecología y obstetricia
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3205.05 Enfermedades Infecciosas
dc.subject.unesco3201.08 Ginecología
dc.titleInfluence of the Human Development Index on the Maternal–Perinatal Morbidity and Mortality of Pregnant Women with SARS-CoV-2 Infection: Importance for Personalized Medical Careen
dc.typejournal article
dc.volume.number10
dspace.entity.typePublication
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