In Vitro Activity of Allium cepa Organosulfur Derivatives against Canine Multidrug-Resistant Strains of Staphylococcus spp. and Enterobacteriaceae

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dc.contributor.authorMaroto Tello, Alba
dc.contributor.authorAyllón Santiago, Tania
dc.contributor.authorAguinaga Casañas, María Arántzazu
dc.contributor.authorAriza, Juan José
dc.contributor.authorPenelo Hidalgo, Silvia
dc.contributor.authorBaños, Alberto
dc.contributor.authorOrtiz Díez, Gustavo
dc.date.accessioned2024-04-26T15:36:36Z
dc.date.available2024-04-26T15:36:36Z
dc.date.issued2024-01-09
dc.descriptionAuthor Contributions: All authors performed the experiments and contributed to data acquisition and analysis. Conceptualization: G.O.-D., A.B. and A.M.-T.; Methodology: A.M.-T., J.J.A. and T.A.; Validation: G.O.-D., A.B., M.A.A.-C., T.A. and S.P.; Writing, review and editing: M.A.A.-C., A.B., G.O.-D., S.P., T.A. and A.M.-T.; supervision, A.B. and G.O.-D. All authors have read and agreed to the published version of the manuscript.
dc.description.abstractBackground: The increase of multi-resistant bacteria, especially Staphylococcus spp. and Enterobacteriaceae, constitutes a challenge in veterinary medicine. The rapid growth of resistance is outpacing antibiotic discovery. Innovative strategies are needed, including the use of natural products like Allium species (Allium sativum L. and Allium cepa L.), which have been used empirically for centuries to treat infectious diseases in humans and farm and aquaculture animals due to their antibacterial properties. Methods: This study aimed to evaluate the in vitro activity of two Alliumderived compounds, propyl propane thiosulfinate (PTS) and propyl propane thiosulfonate (PTSO), against multi-resistant Staphylococcus spp. (n = 30) and Enterobacteriaceae (n = 26) isolated from dogs referred to a veterinary teaching hospital in Madrid. Results and Discussion: The results indicated the in vitro efficacy of PTSO/PTS against the tested bacterial strains, and 56.7% of Staphylococcus pseudintermedius and 53.8% of Enterobacteriaceae showed sensitivity to PTS and PTSO compared with classic antibiotics. In addition, 50% of S. pseudintermedius strains resistant to erythromycin, ibofloxacin, difloxacin and orbifloxacin and 50% of Enterobacteriaceae strains resistant to tetracycline and doxycycline were sensitive to PTS and PTSO. Although studies are needed to verify their efficacy in vivo, the combined use of PTS and PTSO exhibits promise in enhancing bacterial sensitivity against S. pseudintermedius and Enterobacteriaceae infections, providing a first insight into the potential of both compounds in veterinary practice.
dc.description.departmentDepto. de Medicina y Cirugía Animal
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipCentro para el Desarrollo Tecnológico y la Innovación (España)
dc.description.statuspub
dc.identifier.citationMaroto-Tello, A.; Ayllón, T.; Aguinaga-Casañas, M.A.; Ariza, J.J.; Penelo, S.; Baños, A.; Ortiz-Díez, G. In Vitro Activity of Allium cepa Organosulfur Derivatives against Canine Multidrug-Resistant Strains of Staphylococcus spp. and Enterobacteriaceae. Vet. Sci. 2024, 11, 26. https://doi.org/10.3390/vetsci11010026
dc.identifier.doi10.3390/vetsci11010026
dc.identifier.issn2306-7381
dc.identifier.officialurlhttps://doi.org/10.3390/vetsci11010026
dc.identifier.urihttps://hdl.handle.net/20.500.14352/103591
dc.issue.number26
dc.journal.titleVeterinary Sciences
dc.language.isoeng
dc.publisherMDPI
dc.relation.projectIDinfo:eu-repo/grantAgreement/CDTI/FITOPET/IDI-20220251
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu636.09
dc.subject.keywordAntibiotic resistance
dc.subject.keywordAllium extracts
dc.subject.keywordDog
dc.subject.keywordMultidrug-resistant Enterobacteriaceae
dc.subject.keywordMultidrugresistant Staphylococcus spp.
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleIn Vitro Activity of Allium cepa Organosulfur Derivatives against Canine Multidrug-Resistant Strains of Staphylococcus spp. and Enterobacteriaceae
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication
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relation.isAuthorOfPublicationddba7e5a-06bf-4fa7-bf6b-e3d1e63a4631
relation.isAuthorOfPublication62d47891-f33b-4009-a53c-996e05843304
relation.isAuthorOfPublication.latestForDiscovery0f7d7417-a5e6-4dc4-965b-83378dc7079e
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