Publication:
Circulatory follicular helper T lymphocytes associate with lower incidence of CMV infection in kidney transplant recipients

dc.contributor.authorSuárez Fernández, Patricia
dc.contributor.authorUtrero Rico, Alberto
dc.contributor.authorSandonis, Virginia
dc.contributor.authorGarcía Ríos, Estéfani
dc.contributor.authorArroyo Sánchez, Daniel
dc.contributor.authorFernández Ruiz, Mario
dc.contributor.authorAndrés, Amado de
dc.contributor.authorPolanco, Natalia
dc.contributor.authorGonzález Cuadrado, Cecilia
dc.contributor.authorAlmendro Vazquez, Patricia
dc.contributor.authorPérez Romero, Pilar
dc.contributor.authorAguado, José María
dc.contributor.authorPaz Artal, Estela
dc.contributor.authorLaguna Goya, Rocío
dc.date.accessioned2023-06-17T08:22:26Z
dc.date.available2023-06-17T08:22:26Z
dc.date.issued2021-06-21
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2021)
dc.description.abstractPrimary infection and/or reactivation of cytomegalovirus (CMV) in kidney transplant recipients (KTR) favor rejection and mortality. T follicular helper cells (TFH) could contribute to protection against CMV. Circulatory TFH (cTFH) were studied pretransplant and early posttransplant in 90 CMV seropositive KTR not receiving antithymocyte globulin or antiviral prophylaxis, followed-up for 1 year. Patients who presented CMV infection had significantly lower cTFH and activated cTFH pretransplant and early posttransplant. Pretransplant activated cTFH were also lower within patients who developed CMV disease. Pre- and 14 days posttransplant activated cTFH were an independent protective factor for CMV infection (HR 0.41, p = .01; and 0.52, p = .02, respectively). KTR with low cTFH 7 days posttransplant (<11.9%) had lower CMV infection-free survival than patients with high cTFH (28.2% vs. 67.6%, p = .002). cTFH were associated with CMV-specific neutralizing antibodies (Nabs). In addition, IL-21 increased interferon-γ secretion by CMV-specific CD8+ T cells in healthy controls. Thus, we show an association between cTFH and lower incidence of CMV infection, probably through their cooperation in CMV-specific Nab production and IL-21-mediated enhancement of CD8+ T cell activity. Moreover, monitoring cTFH pre- and early posttransplant could improve CMV risk stratification and help select KTR catalogued at low/intermediate risk who could benefit from prophylaxis.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)/ MICINN/ FEDER
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/70569
dc.identifier.doi10.1111/ajt.16725
dc.identifier.issn1600-6135
dc.identifier.officialurlhttps://doi.org/10.1111/ajt.16725
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/10.1111/ajt.16725
dc.identifier.urihttps://hdl.handle.net/20.500.14352/6829
dc.issue.number12
dc.journal.titleAmerican Journal of Transplantation
dc.language.isoeng
dc.page.final3957
dc.page.initial3946
dc.publisherWiley
dc.relation.projectID(PI18/969, PIE13/00045)
dc.relation.projectID(PI17CIII-00014, PI17-01120).
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordbasic (laboratory) research
dc.subject.keywordscience
dc.subject.keywordflow cytometry
dc.subject.keywordimmunobiology
dc.subject.keywordinfection and infectious agents- viral
dc.subject.keywordCytomegalovirus (CMV)
dc.subject.keywordinfectious disease
dc.subject.keywordkidney transplantation
dc.subject.keywordnephrology
dc.subject.keywordtranslational research
dc.subject.ucmInmunología
dc.subject.ucmNefrología y urología
dc.subject.unesco2412 Inmunología
dc.titleCirculatory follicular helper T lymphocytes associate with lower incidence of CMV infection in kidney transplant recipients
dc.typejournal article
dc.volume.number21
dspace.entity.typePublication
relation.isAuthorOfPublication421bef58-af18-4df8-bdc1-398608029e0d
relation.isAuthorOfPublication.latestForDiscovery421bef58-af18-4df8-bdc1-398608029e0d
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
American J Transplantation - 2021 - Su rez‐Fern ndez - Circulatory follicular helper T lymphocytes associate with lower.pdf
Size:
1.09 MB
Format:
Adobe Portable Document Format
Collections