A new technique for feeding dogs with a congenital cleft palate for surgical research

Simple item page
dc.contributor.authorLópez-Gordillo, Yamila et al.
dc.contributor.authorGonzález-Meli, B
dc.contributor.authorMartínez Sanz, Elena
dc.contributor.authorCasado Gómez, Inmaculada
dc.contributor.authorMartín Álvaro, María Concepción
dc.contributor.authorGonzález Aranda, Pablo
dc.contributor.authorParadas Lara, Irene
dc.contributor.authorMaldonado Bautista, Estela
dc.contributor.authorMaestro De Las Casas, María Del Carmen
dc.contributor.authorPrados Frutos, Juan Carlos
dc.contributor.authorMartínez Álvarez, María Concepción
dc.date.accessioned2024-02-14T17:01:51Z
dc.date.available2024-02-14T17:01:51Z
dc.date.issued2011
dc.description.abstractIn humans, cleft palate (CP) is one of the most common malformations. Although surgeons use palatoplasty to close CP defects in children, its consequences for subsequent facial growth have prompted investigations into other novel surgical alternatives. The animal models of CP used to evaluate new surgical treatments are frequently obtained by creating surgically induced clefts in adult dogs. This procedure has been ethically criticized due to its severity and questionable value as an animal model for human CP. Dogs born with a congenital CP would be much better for this purpose, provided they developed CP at a sufficient rate and could be fed. Up until now, feeding these pups carried the risk of aspiration pneumonia, while impeding normal suckling and chewing, and thus compromising orofacial growth. We developed a technique for feeding dog pups with CP from birth to the time of surgery using two old Spanish pointer dog pups bearing a complete CP. This dog strain develops CP in 15-20% of the offspring spontaneously. Custom-made feeding teats and palatal prostheses adapted to the pups' palates were made from thermoplastic plates. This feeding technique allowed lactation, eating and drinking in the pups with CP, with only sporadic rhinitis. To determine whether the use of this palatal prosthesis interferes with palatal growth, the palates of three littermate German shorthaired pointer pups without CP, either wearing or not wearing (controls) the prosthesis, were measured. The results showed that the permanent use of this prosthesis does not impede palatal growth in the pups.
dc.description.departmentDepto. de Anatomía y Embriología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMiisterio de Sanidad de España
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.identifier.citationMartínez-Sanz, E., Casado-Gómez, I., Martín, C., López-Gordillo, Y., González, P., Rodríguez-Bobada, C., ... & Martínez-Álvarez, C. (2011). A new technique for feeding dogs with a congenital cleft palate for surgical research. Laboratory animals, 45(2), 70-80.
dc.identifier.doi10.1258/LA.2010.010044
dc.identifier.issn0023-6772
dc.identifier.officialurlhttps://journals.sagepub.com/doi/10.1258/la.2010.010044?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101441
dc.issue.number2
dc.journal.titleLaboratory Animals
dc.language.isoeng
dc.page.final80
dc.page.initial70
dc.publisherSAGE Publications
dc.relation.projectIDPI06/0184
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu61
dc.subject.keywordCleft palate
dc.subject.keywordDog
dc.subject.keywordRefinement
dc.subject.keywordFeeding technique
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.subject.unesco32 Ciencias Médicas
dc.titleA new technique for feeding dogs with a congenital cleft palate for surgical research
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number45
dspace.entity.typePublication
relation.isAuthorOfPublication5f07d36a-b597-4586-ba12-ab550b70466f
relation.isAuthorOfPublication90f31a9a-857e-49c0-9138-abf0aa34c517
relation.isAuthorOfPublication523be9a6-dc46-4774-9ef0-479abc968f7f
relation.isAuthorOfPublicationf47bb3ba-1fac-4085-ba47-67ec48aeb8dc
relation.isAuthorOfPublicationee58cd27-1d6e-455a-9f27-665e82069dd6
relation.isAuthorOfPublication1c053b34-9bf5-446b-ba75-0444f6aecfb6
relation.isAuthorOfPublication0cb67d29-815e-4ca9-8eac-a3ecdde665fc
relation.isAuthorOfPublication98051620-070c-4fd2-aee6-e7d8e8c7bb54
relation.isAuthorOfPublication0f3bc2a0-1721-498e-8369-fabd836429c1
relation.isAuthorOfPublication.latestForDiscovery5f07d36a-b597-4586-ba12-ab550b70466f
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2011 Martinez-Sanz et al. (Lab Anim).pdf
Size:
3.82 MB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos