Polymorphism in the co-crystallization of the anticonvulsant drug carbamazepine and saccharin using supercritical CO2 as an anti-solvent

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dc.contributor.authorCuadra Mendoza, Isaac Alfonso
dc.contributor.authorCabañas Poveda, Albertina
dc.contributor.authorRodríguez Cheda, José Antonio
dc.contributor.authorPando García-Pumarino, Concepción
dc.date.accessioned2023-12-01T11:20:33Z
dc.date.available2023-12-01T11:20:33Z
dc.date.issued2018
dc.description.abstract1:1 Co-crystals of carbamazepine (CBZ) and saccharin (SAC) were obtained for the first time through the supercritical anti-solvent (SAS) technique based on using supercritical CO2 as anti-solvent. The capability of SAS to produce the desired polymorphic form (two polymorphs are known) was assessed. Operational conditions investigated were temperature (40.0 and 60.0 °C), pressure (10.0 and 15.0 MPa), solvent choice and coformer concentration in the organic solution (CBZ: 30 and 15 mg/mL; SAC: stoichiometric ratio). Co-crystals were characterized in terms of crystallinity and coformers interactions. No homocrystals were present. Using methanol, at 40.0 °C polymorph I was obtained with yields up to 65%; whilst at 60.0 °C a mixture of polymorphs was obtained. Mixtures of polymorphs were also obtained in the ethanol and dichloromethane experiments at the studied conditions while the dimethylsulfoxide experiments failed to produce any co-crystal polymorph. For comparison purposes, pure CBZ and SAC were also processed by SAS.
dc.description.departmentDepto. de Química Física
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.statuspub
dc.identifier.citationCuadra IA, Cabañas A, Cheda JAR, Pando C. Polymorphism in the co-crystallization of the anticonvulsant drug carbamazepine and saccharin using supercritical CO 2 as an anti-solvent . Journal of Supercritical Fluids. 2018;136:60-9.
dc.identifier.doi10.1016/j.supflu.2018.02.004
dc.identifier.issn0896-8446
dc.identifier.officialurlhttps://doi.org/10.1016/j.supflu.2018.02.004
dc.identifier.urihttps://hdl.handle.net/20.500.14352/91023
dc.journal.titleThe Journal of Supercritical Fluids
dc.language.isoeng
dc.page.final69
dc.page.initial60
dc.publisherElsevier
dc.relation.projectIDeu-repo/grantAgreement/MINECO//CTQ2013-41781-P
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu544
dc.subject.keywordCarbon dioxide
dc.subject.keywordPharmaceutical co-crystals
dc.subject.keywordSupercritical anti-solvent
dc.subject.keywordCarbamazepine
dc.subject.keywordSaccharin
dc.subject.keywordApplications
dc.subject.ucmCiencias
dc.subject.ucmQuímica
dc.subject.ucmQuímica física (Química)
dc.subject.unesco23 Química
dc.subject.unesco33 Ciencias Tecnológicas
dc.titlePolymorphism in the co-crystallization of the anticonvulsant drug carbamazepine and saccharin using supercritical CO2 as an anti-solvent
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number136
dspace.entity.typePublication
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relation.isAuthorOfPublication08f9e67b-e7ba-420b-a651-37a03ba04f0c
relation.isAuthorOfPublicationd18bd0a3-b2d5-47ce-bbdc-e2cdad66ac80
relation.isAuthorOfPublication14dc7f21-ee73-46a9-accd-f5a648b5bc0b
relation.isAuthorOfPublication.latestForDiscovery8eb44b53-53de-4d6e-9339-2f0c957e5867
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