Cadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to AB and phosphorylated Tau protein generation and cell death

Simple item page
dc.contributor.authorMoyano-Cires Ivanoff, Paula Viviana
dc.contributor.authorGarcía Sánchez, José Manuel
dc.contributor.authorLobo Alonso, Margarita
dc.contributor.authorAnadón Baselga, María José
dc.contributor.authorSola Vendrell, Emma
dc.contributor.authorPelayo Alarcón, Adela
dc.contributor.authorGarcía Lobo, Jimena
dc.contributor.authorFrejo Moya, María Teresa
dc.contributor.authorPino Sans, Javier Del
dc.date.accessioned2024-02-08T15:06:41Z
dc.date.available2024-02-08T15:06:41Z
dc.date.issued2018-09-11
dc.description.abstractCadmium, a neurotoxic environmental compound, produces cognitive disorders, although the mechanism remains unknown. Cadmium induces a more pronounced cell death on cholinergic neurons from basal forebrain (BF), mediated, in part, by increase in Aβ and total and phosphorylated Tau protein levels, which may explain cadmium effects on learning and memory processes. Cadmium downregulates the expression of heat shock proteins (HSPs) HSP 90, HSP70 and HSP27, and of HSF1, the master regulator of the HSP pathway. HSPs proteins reduce the production of Aβ and phosphorylated Tau proteins and avoid cell death pathways induction. Thus, we hypothesized that cadmium induced the production of Aβ and Tau proteins by HSP pathway disruption through HSF1 expression alteration, leading to BF cholinergic neurons cell death. Our results show that cadmium downregulates HSF1, leading to HSP90, HSP70 and HSP27 gene expression downregulation in BF SN56 cholinergic neurons. In addition, cadmium induced Aβ and total and phosphorylated Tau proteins generation, mediated partially by HSP90, HSP70 and HSP27 disruption, leading to cell death. These results provide new understanding of the mechanisms contributing to cadmium harmful effects on cholinergic neurons.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipBanco Santander
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationCadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to AB and phosphorylated Tau protein generation and cell death. Paula Moyano, Jose Manuel García, Margarita Lobo, María José Anadon, Emma Sola, Adela Pelayo, Jimena García, Maria Teresa Frejo, Javier del Pino. Food and Chemical Toxicology 121 (2018): 297-308
dc.identifier.doi10.1016/j.fct.2018.09.016
dc.identifier.essn1873-6351
dc.identifier.issn0278-6915
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0278691518306604?via=ihub
dc.identifier.pmid30213552
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/30213552/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100512
dc.journal.titleFood and Chemical Toxicology
dc.language.isoeng
dc.page.final308
dc.page.initial297
dc.publisherElsevier
dc.relation.projectIDPR26-20326
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keywordCadmium neurotoxicity
dc.subject.keywordCognitive disorders
dc.subject.keywordHSF1
dc.subject.keywordHeat shock proteins
dc.subject.keywordSN56 basal forebrain cholinergic neurons
dc.subject.ucmToxicología (Medicina)
dc.subject.ucmNeurociencias (Medicina)
dc.subject.unesco3214 Toxicología
dc.subject.unesco3205.07 Neurología
dc.titleCadmium alters heat shock protein pathways in SN56 cholinergic neurons, leading to AB and phosphorylated Tau protein generation and cell death
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number121
dspace.entity.typePublication
relation.isAuthorOfPublicationa32b2ca4-7685-43b3-a38b-f2fc89f53a26
relation.isAuthorOfPublicationbcdb7018-edab-4918-bc34-ee98b7f1c7f7
relation.isAuthorOfPublicationec8b16ca-d52e-4677-ad42-22625a8ee7cc
relation.isAuthorOfPublication5e0eedb6-ac54-4712-85be-f766f0bfa397
relation.isAuthorOfPublication6e3cc1f8-77ba-4df6-8972-0757f2adb053
relation.isAuthorOfPublication0f2b9a73-5d54-4a43-ab42-d1aa098664e0
relation.isAuthorOfPublication21dd3fad-4e0a-4400-b13f-6a8477f64ece
relation.isAuthorOfPublication4ee3645d-5d2c-4b55-bea6-887e004b9aa3
relation.isAuthorOfPublicationf892dbdb-0feb-4146-95e7-8114d93c2711
relation.isAuthorOfPublication.latestForDiscoverya32b2ca4-7685-43b3-a38b-f2fc89f53a26
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Cadmium alters heat shock protein pathways.pdf
Size:
4.55 MB
Format:
Adobe Portable Document Format
Download
Collections
Artículos