New photocrosslinked 3D foamed scaffolds based on GelMA copolymers: potential application in bone tissue engineering

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dc.contributor.authorPablos Lagartos, Jesús Luis
dc.contributor.authorJiménez Holguín, Javier
dc.contributor.authorSánchez Salcedo, Sandra
dc.contributor.authorSalinas Sánchez, Antonio Jesús
dc.contributor.authorCorrales, Teresa
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.editorMDPI
dc.date.accessioned2024-04-30T10:54:38Z
dc.date.available2024-04-30T10:54:38Z
dc.date.issued2023-05-11
dc.description2023 Descuentos MDPI
dc.description.abstractThe production of customized polymeric hydrogels in the form of 3D scaffolds with application in bone tissue engineering is currently a topic of great interest. Based on gelatin methacryloyl (GelMa) as one of the most popular used biomaterials, GelMa with two different methacryloylation degrees (DM) was obtained, to achieve crosslinked polymer networks by photoinitiated radical polymerization. In this work, we present the obtention of new 3D foamed scaffolds based on ternary copolymers of GelMa with vinylpyrrolidone (VP) and 2-hydroxyethylmethacrylate (HEMA). All biopolymers obtained in this work were characterized by infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), whose results confirm the presence of all copolymers in the crosslinked biomaterial. In addition, scanning electron microscopy (SEM) pictures were obtained verifying the presence of the porosity created by freeze-drying process. In addition, the variation in its swelling degree and its enzymatic degradation in vitro was analyzed as a function of the different copolymers obtained. This has allowed us to observe good control of the variation in these properties described above in a simple way by varying the composition of the different comonomers used. Finally, with these concepts in mind, biopolymers obtained were tested through assessment of several biological parameters such as cell viability and differentiation with MC3T3-E1 pre-osteoblastic cell line. Results obtained show that these biopolymers maintain good results in terms of cell viability and differentiation, along with tunable properties in terms of hydrophilic character, mechanical properties and enzymatic degradation. © 2023 by the authors.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.fundingtypePagado por el autor
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III (España)
dc.description.sponsorshipEuropean Research Council
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.statuspub
dc.identifier.citationPablos, J.L.; Jiménez-Holguín, J.; Salcedo, S.S.; Salinas, A.J.; Corrales, T.; Vallet-Regí, M. New Photocrosslinked 3D Foamed Scaffolds Based on GelMA Copolymers: Potential Application in Bone Tissue Engineering. Gels 2023, 9, 403. https://doi.org/10.3390/gels9050403
dc.identifier.doi10.3390/gels9050403
dc.identifier.essn2310-2861
dc.identifier.officialurlhttps://doi.org/10.3390/gels9050403
dc.identifier.urihttps://hdl.handle.net/20.500.14352/103690
dc.issue.number5
dc.journal.titleGels
dc.language.isoeng
dc.page.final403-23
dc.page.initial403-1
dc.publisherMDPI
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PID2021-124926NB-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F01384/ES/DISEÑO DE UN NUEVO BIOMATERIAL CON POTENCIAL OSTEOINDUCTOR PARA EL TRATAMIENTO DE DEFECTOS OSEOS/
dc.relation.projectID694160
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu539.199
dc.subject.cdu54
dc.subject.keywordGelMa copolymers
dc.subject.keywordTunable properties
dc.subject.keywordCytocompatible polymers
dc.subject.keywordCell proliferation
dc.subject.keywordDifferentiation
dc.subject.keywordTissue engineering
dc.subject.keywordBone regeneration
dc.subject.ucmQuímica
dc.subject.unesco2304 Química Macromolecular
dc.titleNew photocrosslinked 3D foamed scaffolds based on GelMA copolymers: potential application in bone tissue engineering
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery9de111a3-2d20-4570-86ff-30a690c493ee
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