Ribotoxins are a more widespread group of proteins within the filamentous fungi than previously believed

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dc.contributor.authorMartínez Ruiz, Antonio
dc.contributor.authorRichard Kao
dc.contributor.authorJulian Davies
dc.contributor.authorMartínez Del Pozo, Álvaro
dc.date.accessioned2024-04-04T09:45:49Z
dc.date.available2024-04-04T09:45:49Z
dc.date.issued1999-11
dc.description.abstracta-Sarcin, restrictocin and mitogillin are the best known members of the family of fungal ribotoxins. In recent years, new members of this family have been discovered and characterised. In this work, we study the occurrence of ribotoxins among di erent species of fungi. The presence of ribotoxins has been identi®ed in some new species by means of genetic studies, as well as expression and activity assays. The ribotoxin genes have been partially sequenced, and demonstrate a high degree of similarity. These studies demonstrate that these toxins are more widespread than previously considered. This is surprising, considering the ribotoxins are such speci®c and potent toxins, of unknown biological function. These studies con®rm the hypothesis that these proteins are naturally engineered toxins derived from ribonucleases of broad substrate speci®city.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationA. Martínez-Ruiz et al. Toxicon 37, 11 (1999) 1549-1563
dc.identifier.doi10.1016/s0041-0101(99)00103-8
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102700
dc.issue.number11
dc.journal.titleToxicon
dc.language.isoeng
dc.page.final1563
dc.page.initial1549
dc.rights.accessRightsopen access
dc.subject.cdu577.1
dc.subject.ucmBioquímica (Química)
dc.subject.unesco2302 Bioquímica
dc.titleRibotoxins are a more widespread group of proteins within the filamentous fungi than previously believed
dc.typejournal article
dc.volume.number37
dspace.entity.typePublication
relation.isAuthorOfPublicationeec0b303-34c9-47dd-9ec6-704b6c6c7acd
relation.isAuthorOfPublication4d35a8a6-8bd3-4ff4-b179-57581d8d36d8
relation.isAuthorOfPublication.latestForDiscoveryeec0b303-34c9-47dd-9ec6-704b6c6c7acd
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