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Desarrollo de un modelo bovino de infección experimental por "Besnoitia besnoiti"

dc.contributor.advisorÁlvarez García, Gema
dc.contributor.advisorFerre Pérez, Ignacio
dc.contributor.advisorBlanco Murcia, Francisco Javier
dc.contributor.authorDiezma Díaz, Carlos
dc.date.accessioned2023-06-17T11:14:18Z
dc.date.available2023-06-17T11:14:18Z
dc.date.defense2019-11-11
dc.date.issued2020-04-01
dc.descriptionTesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Sanidad Animal, leída el 11-11-2019
dc.description.abstractLa besnoitiosis bovina, causada por el protozoo apicomplejo Besnoitia besnoiti, es una enfermedad crónica y debilitante del ganado vacuno caracterizada por signos clínicos locales y sistémicos. La European Food Safety Authority (EFSA) consideró a la besnoitiosis bovina como una enfermedad re-emergente en Europa debido a un notable aumento en el número de casos. Actualmente, el control de la enfermedad solo es posible mediante medidas de manejo asociadas a un diagnóstico temprano, ya que fármacos y/o vacunas no están disponibles en Europa.Se han testado in vitro diversos fármacos efectivos contra el estadio de taquizoíto responsable de la fase aguda de la enfermedad. Sin embargo, estos candidatos terapéuticos no han sido probados en un modelo animal de infección experimental ya que, por el momento, no está disponible. Se han infectado diversas especies de roedores de laboratorio con resultados inconclusos. Únicamente, los conejos han mostrado cierta susceptibilidad a la infección, manifestando signos clínicos de la fase aguda y de la fase crónica...
dc.description.abstractBovine besnoitiosis, caused by the cyst forming apicomplexan parasite Besnoitia besnoiti, is a chronic and a debilitating cattle disease characterized by both local and systemic manifestations. It is considered re-emerging by the European Food Safety Authority due to an increase number of cases in Western and Central European countries. Currently, the control of this disease is only possible through management measures coupled to diagnosis since chemotherapeutics are not available and no vaccines are licensed in Europe.Several drugs have been tested in in vitro systems for their efficacy against B. besnoiti tachyzoites responsible for the acute stage. As a next step, these drugs should be tested in experimental animal models that are not available yet. Laboratory rodent species have been infected with B. besnoiti showing inconclusive results. Rabbits showed susceptibility to experimental infection by developing clinical signs compatible with acute and chronic phases of the disease. However, the establishment of B. besnoiti and its adaptation to a heterologous host is difficult...
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.statusunpub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/59849
dc.identifier.urihttps://hdl.handle.net/20.500.14352/11127
dc.language.isospa
dc.page.total265
dc.publication.placeMadrid
dc.publisherUniversidad Complutense de Madrid
dc.rights.accessRightsopen access
dc.subject.cdu636.2(043.2)
dc.subject.keywordGanado vacuno
dc.subject.keywordCattle
dc.subject.ucmGanado vacuno
dc.subject.unesco3104.07 Ovinos
dc.titleDesarrollo de un modelo bovino de infección experimental por "Besnoitia besnoiti"
dc.typedoctoral thesis
dspace.entity.typePublication
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